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Last Updated: December 19, 2025

Claims for Patent: 11,498,913

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Summary for Patent: 11,498,913

Title:	Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Abstract:	The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
Inventor(s):	Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, Jr., Justin Andrew Caravella, Wei Lu
Assignee:	Forma Therapeutics Inc
Application Number:	US17/101,018
Patent Claims:	1. A composition comprising a compound: or salt thereof, in an enantiomeric purity (e.g. %) of at least 98% as determined by chiral HPLC analysis. 2. The composition of claim 1, further comprising a compound: 3. The composition of claim 1, further comprising a compound: 4. The composition of claim 3, further comprising a compound: 5. A composition comprising a compound: or salt thereof, obtained by a process comprising a step of contacting a compound: or salt thereof, with a compound: or salt thereof, to provide the compound: or salt thereof. 6. The composition of claim 5, wherein the process further comprises a step of preparing the compound: or salt thereof, by a process comprising a step of reacting the compound: with a suitable base to form the compound: or salt thereof. 7. The composition of claim 6, wherein the process further comprises a step of preparing the compound: by a process comprising a step of reacting the compound: with acetic anhydride to form the compound: 8. The composition of claim 7, wherein the process further comprises a step of preparing the compound: by a process comprising a step of reacting the compound: or salt thereof, with a suitable oxidizing agent to form the compound: 9. The composition of claim 5, wherein the process further comprises a step of preparing the compound: or salt thereof, by a process comprising a step of reacting the compound: or salt thereof, with a suitable acid to form the compound: or salt thereof. 10. The composition of claim 9, wherein the process further comprises a step of preparing the compound: or salt thereof, by a process comprising a step of reacting the compound: with MeMgBr to form the compound: or salt thereof. 11. The composition of claim 10, wherein the process further comprises a step of preparing the compound: by a process comprising a step of reacting 2,6-dichloroquinoline-3-carbaldehyde: with: to form the compound: 12. The composition of claim 6, wherein the suitable base is K2CO3. 13. The composition of claim 8, wherein the suitable oxidizing agent is m-CPBA. 14. The composition of claim 9, wherein the suitable acid is HCl. 15. A composition comprising (i) the compound: or a salt thereof; and (ii) at least one compound selected from the group consisting of: or a salt thereof. 16. The composition of claim 15, wherein the composition comprises the compound: or a salt thereof. 17. The composition of claim 15, wherein the composition comprises the compound: or a salt thereof. 18. The composition of claim 15, wherein the composition comprises both compounds: or a salt thereof.

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