Claims for Patent: 11,446,441

Summary for Patent: 11,446,441

Title:	Prefilled syringe injector
Abstract:	A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.
Inventor(s):	Lesch, Jr.; Paul R. (Lino Lakes, MN)
Assignee:	ANTARES PHARMA, INC. (Ewing, NJ)
Application Number:	16/599,836
Patent Claims:	1. An injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament; a distal portion and a proximal portion opposite the distal portion; a needle disposed at the distal portion of the prefilled syringe, the needle having an injecting tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the fluid chamber for injecting the medicament from the fluid chamber into an injection site; a plunger movable within the fluid chamber; and a housing housing the prefilled syringe and configured for allowing insertion of the needle at the injection site to an insertion point that is at a penetration depth below a surface at the insertion location; a syringe support fixing the prefilled syringe to the housing and axially supporting the proximal portion of the prefilled syringe during the injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction; and an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber to inject the medicament from the fluid chamber through the needle to the injection site. 2. The injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains below about 500 psi and above about 90 psi during the injection of the medicament. 3. The injector of claim 1, wherein the energy source is configured to produce the injecting pressure that remains at least at about 100 psi during the injection of the medicament. 4. The injector of claim 3, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains up to about 350 psi during the injection of the medicament. 5. The injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 0.5 mm and 5 mm below the surface at the insertion location. 6. The injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 11 mm and 13 mm below the surface at the insertion location. 7. The injector of claim 1, wherein the energy source comprises a spring. 8. The injector of claim 7, further comprising a ram that is biased by the spring against the plunger to produce the injecting pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the injector is fired, such that the spring surrounds the prefilled syringe. 9. The injector of claim 1, wherein the container portion of the prefilled syringe is made of blown glass. 10. The injector of claim 9, wherein the needle is adhered to the blown glass. 11. The injector of claim 1, wherein the fluid chamber contains about between 0.02 mL and 4 mL of the medicament. 12. The injector of claim 1, wherein the housing comprises a retractable guard that is movable between: a protecting position in which the needle is disposed within the retractable guard; and an injecting position in which the injection tip of the needle is exposed for insertion to the insertion point. 13. The injector of claim 12, further comprising a trigger mechanism operably associated with the energy source for activating the energy source to inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the retractable guard is retracted from the protecting position. 14. The injector of claim 13, wherein the retractable guard is operably associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the retractable guard is retracted to the injecting position. 15. The injector of claim 1, wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament. 16. The injector of claim 1, further comprising a syringe cushion associated with the syringe support and prefilled syringe to compensate for shape irregularities of the prefilled syringe.