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Last Updated: May 6, 2024

Claims for Patent: 11,344,512

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Summary for Patent: 11,344,512

Title:	Titration of tapentadol
Abstract:	The use of tapentadol for the manufacture of a medicament comprising at least one administration unit A containing dose a of tapentadol and at least one administration unit B containing dose b of tapentadol, where dose a<dose b, for the treatment of pain.
Inventor(s):	Lange; Claudia (Wiesloh, DE), Rombout; Ferdinand (NL-Klimmen, NL)
Assignee:	Grunenthal GmbH (Aachen, DE)
Application Number:	16/439,135
Patent Claims:	1. A method of treating pain with a lower incidence of somnolence in a subject in need thereof, said method comprising orally administering to said subject: (i) a first dose of tapentadol of 50 mg.+-.5% or 100 mg.+-.5% twice daily (bid) during a first administration interval of at least 1-3 days; (ii) a second dose of tapentadol calculated by increasing said first dose by 50 mg to 100 mg.+-.5% or 150 mg.+-.5% twice daily (bid), respectively, during a second administration interval of at least 3-11 days following said first administration interval; and (iii) a third dose of tapentadol calculated by increasing said second dose by 50 mg to 150 mg.+-.5% or 200 mg.+-.5% twice daily (bid), respectively, during a third administration interval of at least 3-14 days following said second administration interval. 2. The method according to claim 1, which comprises orally administering to said subject: (i) a first dose of tapentadol of 50 mg.+-.5% twice daily (bid) during the first administration interval of at least 1-3 days; (ii) a second dose of tapentadol of 100 mg.+-.5% twice daily (bid) during the second administration interval of at least 3-11 days following said first administration interval; and (iii) a third dose of tapentadol of 150 mg.+-.5% twice daily (bid) during the third administration interval of at least 3-14 days following said second administration interval. 3. The method according to claim 1, which comprises orally administering to said subject: (i) a first dose of tapentadol of 100 mg.+-.5% twice daily (bid) during the first administration interval of at least 1-3 days; (ii) a second dose of tapentadol of 150 mg.+-.5% twice daily (bid) during the second administration interval of at least 3-11 days following said first administration interval; and (iii) a third dose of tapentadol of 200 mg.+-.5% twice daily (bid) during the third administration interval of at least 3-14 days following said second administration interval.

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