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Last Updated: December 12, 2025

Claims for Patent: 11,291,728

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Summary for Patent: 11,291,728

Title:	Anhydrous sodium thiosulfate and formulations thereof
Abstract:	Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum based chemotherapeutics.
Inventor(s):	Thomas Claiborne Lovelace, Joseph Alexander MOORE, III, Christopher McKinnon LEE, Daniel Logan KIRSCHNER
Assignee:	Ads Pharma Consulting LLC , Avista Pharma Solutions Inc , Fennec Pharmaceuticals Inc
Application Number:	US17/005,997
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,291,728
Patent Claims:	1. A pharmaceutical composition comprising aqueous anhydrous sodium thiosulfate, wherein the aqueous anhydrous sodium thiosulfate is at a concentration of about 0.5 M and further comprising about 0.004 M boric acid. 2. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition has a total volume of about 100 mL. 3. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition further comprises hydrochloric acid. 4. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition further comprises hydrochloric acid. 5. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition further comprises sodium hydroxide. 6. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition further comprises sodium hydroxide. 7. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition has a pH between about 5 and about 9.5. 8. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition has a pH between about 6.5 and about 8.9. 9. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition has a pH between about 8.6 and about 8.8.

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