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Last Updated: May 20, 2024

Claims for Patent: 11,266,622


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Summary for Patent: 11,266,622
Title:Method of treatment
Abstract: Embodiments of the invention relate to the treatment of sleep disturbances in individuals with Smith-Magenis Syndrome (SMS).
Inventor(s): Lavedan; Christian (Potomac, MD), Polymeropoulos; Mihael H. (Potomac, MD)
Assignee: VANDA PHARMACEUTICALS INC. (Washington, DC)
Application Number:16/848,150
Patent Claims: 1. A method of treating a patient suffering from Smith-Magenis Syndrome (SMS), the method comprising: administering to the patient 20 mg of tasimelteon once daily before bedtime.

2. The method of claim 1, wherein treating comprises one or more of the following: increasing total nighttime sleep; or reducing in number nighttime awakenings; or reducing in length nighttime awakenings.

3. The method of claim 1, wherein treating comprises one or more of the following: advancing sleep onset; or reducing wake time; or reducing in number daytime naps.

4. The method of claim 1, wherein treating comprises one of more of the following: improving clinical global impression of change (CGI-C); or improving clinical global impression of severity (CGI-S).

5. The method of claim 1, wherein administering includes administering the tasimelteon between one-half hour and two hours before bedtime.

6. The method of claim 5, wherein administering includes administering the tasimelteon between one-half hour and one-and-one-half hours before bedtime.

7. The method of claim 6, wherein administering includes administering the tasimelteon one hour before bedtime.

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