Claims for Patent: 11,026,901

Summary for Patent: 11,026,901

Title:	Treatment or prevention of cardiovascular events via the administration of a colchicine derivative
Abstract:	A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and R5′, R5″, R6′ and R6″ independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.
Inventor(s):	Mark Nidorf
Assignee:	Murray and Poole Enterprises Ltd
Application Number:	US17/103,683
Patent Claims:	1. A method for treating and/or reducing the risk of acute myocardial infarction in a subject comprising: administering to the subject a therapeutically effective amount of a composition comprising about 0.5 total mg of (i) colchicine, (ii) a salt of (i), or any combination of (i) and (ii), wherein the composition is administered orally and once per day. 2. The method of claim 1, wherein the composition is administered in the form of a tablet or capsule. 3. The method of claim 1, wherein the composition is administered in the form of a liquid dose, gel, or powder. 4. The method of claim 1, wherein the subject has a previous diagnosis of diabetes, past myocardial infarction, unstable angina, coronary bypass surgery, and/or coronary angioplasty. 5. The method of claim 1, wherein the subject is from about 35 to about 85 years of age. 6. The method of claim 1, wherein the acute myocardial infarction is non-stent related acute myocardial infarction. 7. The method of claim 1, wherein the subject is administered the composition daily for at least 24 months. 8. The method of claim 1, wherein the subject is administered the composition daily for at least 36 months. 9. The method of claim 1, wherein the subject is administered the composition daily for at least 44 months. 10. A method for treating and/or reducing the risk of acute myocardial infarction in a subject comprising: administering to the subject a therapeutically effective amount of a composition comprising no more than about 0.6 total mg of (i) colchicine, (ii) a salt of (i), or any combination of (i) and (ii), wherein the composition is administered orally and once per day. 11. The method of claim 10, wherein the composition is administered in the form of a tablet or capsule. 12. The method of claim 10, wherein the composition is administered in the form of a liquid dose, gel, or powder. 13. The method of claim 10, wherein the subject has a previous diagnosis of diabetes, past myocardial infarction, unstable angina, coronary bypass surgery, and/or coronary angioplasty. 14. The method of claim 10, wherein the subject is from about 35 to about 85 years of age. 15. The method of claim 10, wherein the acute myocardial infarction is non-stent related acute myocardial infarction. 16. The method of claim 10, wherein the subject is administered the composition daily for at least 24 months. 17. The method of claim 10, wherein the subject is administered the composition daily for at least 36 months. 18. The method of claim 10, wherein the subject is administered the composition daily for at least 44 months.