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Last Updated: May 3, 2024

Claims for Patent: 11,020,382

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Summary for Patent: 11,020,382

Title:	Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde
Abstract:	Provided herein are methods for treating sickle cell disease, comprising administering to a subject 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)-methoxy)benzal- dehyde (Compound 1), or a polymorph thereof, in certain dosing regimens.
Inventor(s):	Ramos; Eleanor L. (South San Francisco, CA), Lehrer-Graiwer; Joshua Eli (South San Francisco, CA), Hutchaleelaha; Athiwat (South San Francisco, CA)
Assignee:	Global Blood Therapeutics, Inc. (South San Francisco, CA)
Application Number:	15/368,142
Patent Claims:	1. A method for treating sickle cell disease in a human patient in need thereof comprising administering to the patient Compound 1: ##STR00003## wherein Compound 1 is administered orally in a dose of about 1500 mg once daily; and Compound 1 is in a crystalline ansolvate form characterized by X-ray powder diffraction peaks (Cu K.alpha. radiation) at 13.37.degree., 14.37.degree., 19.95.degree. and 23.92.degree. 2.theta., each peak is .+-.0.2.degree. 2.theta.. 2. A method for increasing hemoglobin to treat sickle cell disease in a human patient in need thereof comprising administering to the patient Compound 1: ##STR00004## wherein Compound 1 is administered orally in a dose of about 1500 mg once daily; and Compound 1 is in a crystalline ansolvate form characterized by X-ray powder diffraction peaks (Cu K.alpha. radiation) at 13.37.degree., 14.37.degree., 19.95.degree. and 23.92.degree. 2.theta., each peak is .+-.0.2.degree. 2.theta..

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