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Last Updated: April 17, 2026

Claims for Patent: 10,875,839

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Summary for Patent: 10,875,839

Title:	Somatostatin modulators and uses thereof
Abstract:	Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.
Inventor(s):	Jian Zhao, Shimiao Wang, Yunfei ZHU
Assignee:	Crinetics Pharmaceuticals Inc
Application Number:	US16/712,620
Patent Claims:	1. A method of treating acromegaly in a human comprising orally administering to the human with acromegaly a pharmaceutical composition comprising a therapeutically effective amount of a compound that has the following structure: or a pharmaceutically acceptable salt, or solvate thereof; and at least one pharmaceutically acceptable excipient; wherein the pharmaceutical composition is in the form of a tablet, a pill, or a capsule. 2. The method of claim 1, wherein the pharmaceutical composition is in the form of a tablet. 3. The method of claim 1, wherein the pharmaceutical composition is in the form of a capsule. 4. The method of claim 1, wherein the composition is administered once per day, twice per day, three times per day, or four times per day. 5. The method of claim 4, wherein the composition is administered once per day. 6. The method of claim 1, wherein the composition is in the form of a capsule and is administered once per day. 7. The method of claim 1, wherein the pharmaceutical composition comprises a therapeutically effective amount of a compound that has the following structure: or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. 8. The method of claim 7, wherein the composition is in the form of a capsule and is administered once per day. 9. The method of claim 7, wherein the composition is in the form of a tablet and is administered once per day. 10. The method of claim 1, wherein the composition is in the form of a tablet and is administered once per day.

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