Claims for Patent: 10,836,755

Summary for Patent: 10,836,755

Title:	Cardiac sarcomere inhibitors
Abstract:	Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Inventor(s):	Chihyuan Chuang, Bradley P. Morgan, Mark VANDERWAL, Wenyue Wang, Luke W. Ashcraft
Assignee:	Cytokinetics Inc
Application Number:	US16/252,483
Patent Claims:	1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: G1 is —CR4R5; G2 is a bond; G3 is —CR8; R1, R3, R4, R5, and R8 are each independently H, C1-C6 alkyl, halo, or hydroxyl; R2 is H, C2-C6 alkyl, halo, or hydroxyl; Z is a bond A is 5- or 6-membered heteroaryl comprising at least one annular N atom, wherein the 5- or 6-membered heteroaryl is unsubstituted or substituted with one or more R10 substituents; each R10 is independently selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and —C(O)ORa; B is heteroaryl, wherein the heteroaryl of B is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, unsubstituted C1-C6 alkyl, C1-C6alkyl substituted with one or more R12 substituents, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, halo, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf; each R12 is independently selected from the group consisting of halo, —ORb, —C(O)Rg, —C(O)ORh, and —C(O)NRiRj; and each Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, and Rj is independently H or C1-C6 alkyl. 2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula (I) is a compound of Formula (If): 3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and R8 are each H. 4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein G1 is —CH2—. 5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein G3 is —CH—. 6. The compound of claim 1, wherein R1, R2, and R3 are each H. 7. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is 5-membered heteroaryl comprising at least one annular N atom, wherein the 5-membered heteroaryl is unsubstituted or substituted with one or more R10 substituents. 8. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of pyrazolyl, oxazolyl, oxadiazolyl, isoxazolyl, tetrazolyl, triazolyl, thiazolyl, pyrimidinyl, pyridinyl, pyrazinyl, and pyridazinyl, each of which is unsubstituted or substituted with one or more R10 substituents. 9. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl or isoxazolyl, each of which is unsubstituted or substituted with one or more R10 substituents. 10. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of: each of which is unsubstituted or substituted with one or more R10 substituents. 11. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein each C1-C6 alkyl, cycloalkyl, or heterocycloalkyl of R10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —ORk and —OC(O)Rm, wherein Rk and Rm are each independently H or C1-C6 alkyl. 12. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein each R10 is independently selected from the group consisting of —C(O)OCH3, methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl, wherein each methyl, ethyl and isopropyl of R10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —OCH3, —OH, and —OC(O)CH3. 13. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, methyl substituted with —OCH3, —OH, or —OC(O)CH3, ethyl, ethyl substituted with —OCH3, —OH, or —OC(O)CH3, isopropyl, isopropyl substituted with —OCH3, —OH, or —OC(O)CH3, difluoromethyl, cyclopropyl, cyclobutyl, oxetanyl, and —C(O)OCH3. 14. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, and cyclobutyl. 15. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is isoxazolyl, which is unsubstituted or substituted with one or more substituents selected from the group consisting of methyl, ethyl, and difluoromethyl. 16. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is isoxazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, ethyl, and difluoromethyl. 17. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of: wherein each R13 is independently selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and —C(O)ORa; and Ra is H or C1-C6 alkyl. 18. The compound of claim 17, or a pharmaceutically acceptable salt thereof, wherein each R13 is independently selected from the group consisting of H, —C(O)OCH3, methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl, wherein each methyl, ethyl and isopropyl of R13 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —OCH3, —OH, and —OC(O)CH3. 19. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered heteroaryl, wherein the 5- or 6-membered heteroaryl of B is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C1-C6 alkyl, halo, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf, wherein each heterocycloalkyl and heteroaryl of R11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, —C(O)Rn, —C(O)ORp, and —C(O)NRqRr; and each Rb, Rc, Rd, Re, Rf, Rn, Rp, Rq, and Rr is independently H or C1-C6 alkyl. 20. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered monocyclic heteroaryl comprising at least one annular N atom or 8- or 9-membered bicyclic heteroaryl comprising at least one annular N atom, each of which is substituted or unsubstituted. 21. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered monocyclic heteroaryl comprising at least one annular N atom or 8- or 9-membered bicyclic heteroaryl comprising at least one annular N atom, each of which is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C1-C6 alkyl, halo, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf, wherein each heterocycloalkyl and heteroaryl of R11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, —C(O)Rn, —C(O)ORp, and —C(O)NRqRr, and wherein each C1-C6 alkyl of R11 is unsubstituted or substituted with —ORb; and each Rb, Rc, Rd, Re, Rf, Rn, Rp, Rq, and Rr is independently H or C1-C6 alkyl. 22. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of thiazolyl, triazolyl, imidazolyl, pyrazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrimidinyl, pyridinyl, pyrrolopyrazolyl and benzoimidazolyl, each of which is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C1-C6 alkyl, halo, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf, wherein each heterocycloalkyl and heteroaryl of R11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, —C(O)Rn, —C(O)ORp, and —C(O)NRqRr, and wherein each C1-C6 alkyl of R11 is unsubstituted or substituted with —ORb; and each Rb, Rc, Rd, Re, Rf, Rn, Rp, Rq, and Rr is independently H or C1-C6 alkyl. 23. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein each R11 is independently selected from the group consisting of methyl, ethyl, isopropyl, cyclopropyl, difluoromethyl, trifluoromethyl, oxo, —C(O)CH3, —C(O)OtBu, —OCH3, —OH, —NH2, —Cl, oxetanyl, oxadiazolyl, and azetidinyl, wherein each oxadiazolyl and azetidinyl of R11 is unsubstituted or substituted with one or more substituents selected from the group consisting of ethyl, —C(O)CH3, —C(O)OtBu, —C(O)OCH3, —C(O)NHCH3, —C(O)NH2, and —OCH3, and wherein each methyl, ethyl, and isopropyl of R11 is unsubstituted or substituted with —OH. 24. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl, oxazolyl, tetrazolyl, isoxazolyl, thiazolyl, imidazolyl, or pyridinyl, each of which is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C1-C6 alkyl, C1-C6 alkyl substituted with one or two R12 substituents, cycloalkyl, cycloalkyl substituted with one or two R12 substituents, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf; each R12 is independently selected from the group consisting of halo, —ORb, —C(O)Rg, —C(O)ORh, and —C(O)NRiRj; and each Rb, Rc, Rd, Re, and Rf, Rg, Rh, Ri, and Rj is independently H or C1-C6 alkyl. 25. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl, oxazolyl, tetrazolyl, isoxazolyl, thiazolyl, imidazolyl, or pyridinyl, each of which is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C1-C6 alkyl, C1-C6 alkyl substituted with one or two R12 substituents, cycloalkyl, cycloalkyl substituted with one or two R12 substituents, fluoroalkyl, —ORb, oxo, and —NReRf; each R12 is independently selected from the group consisting of halo, —ORb, and —C(O)NRiRj; and each Rb, Re, Rf, Ri, and Rj is independently H or C1-C6 alkyl. 26. The compound of claim 25, or a pharmaceutically acceptable salt thereof, wherein Rb is H. 27. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of: each of which is unsubstituted or substituted with one or more R11 substituents; each R11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C1-C6 alkyl, C1-C6 alkyl substituted with one or two R12 substituents, cycloalkyl, cycloalkyl substituted with one or two R12 substituents, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf; each R12 is independently selected from the group consisting of halo, —ORb, —C(O)Rg, —C(O)ORh, and —C(O)NRiRj; and each Rb, Rc, Rd, Re, and Rf, Rg, Rh, Ri, and Rj is independently H or C1-C6 alkyl. 28. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of: wherein each R14 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, cycloalkyl substituted with one or two R12 substituents, aryl, C1-C6 alkyl, C1-C6 alkyl substituted with one or two R12 substituents, halo, fluoroalkyl, —ORb, —C(O)Rc, —C(O)ORd, oxo, and —NReRf, wherein each heterocycloalkyl and heteroaryl of R14 is unsubstituted or substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, —C(O)Rn, —C(O)ORp, and —C(O)NRqRr; each R12 is independently selected from the group consisting of halo, —ORb, —C(O)Rg, —C(O)ORh, and —C(O)NRiRj; and each Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, and Rj, Rn, Rp, Rq, and Rr is independently H or C1-C6 alkyl. 29. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of: Structure Name 2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylisonicotinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-imidazole- 5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole- 4-carboxamide; 2-chloro-N-(5-(5-(difluoromethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)thiazole-5-carboxamidc; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methylthiazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)thiazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-ethyl-5-methyl-2H- 1,2,3-triazole-4-carboxamide; 4-cyclopropyl-N-(5-(5- (difluoromethyl)-,1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2,5-dimethyloxazole-4- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-methylpyrazine-2- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2,6 dimethylisonicotinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-3-ethyl-1-methyl-1H- pyrazole-4-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylpyrimidine-4- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,5-dimethyl-1H- pyrazole-4-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,3-dimethyl-1H- pyrazole-4-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-ethyl-1H-pyrazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,3-dimethyl-1H- pyrazole-5-carboxamide; (R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; (R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylisonicotinamide; 2-amino-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; 3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5,6-dihydro-4H-pyrrolo[1,2- b]pyrazole-3-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-methylpyridazine-4- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylpyrazine-2- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylnicotinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-3-(trifluoromethyl)-1H- pyrazole-4-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3,5-dimethylpyrazine-2- carboxamide; 2-hydroxy-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide; 2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-1,2,3-triazole-4-carboxamide; 1,2-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-imidazole-5-carboxamide; 5-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-4-carboxamide; 1,3-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; (R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; 4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; 4-cyclopropyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; 2,4-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; 1,5-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; 1,3-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; 1-ethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; N-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-5,6- dihydro-4H-pyrrolo[1,2-b]pyrazole-3- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylpicolinamide; 3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)picolinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazo1-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylthiazole-2-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 3-yl)urea; 4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)thiazole-2-carboxamide; 2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; 1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylpicolinamide; 4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)picolinamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide; 3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methylisoxazole-4- carboxamide; N-(5-(5-cyclopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide; (3-(1-(1,3-dimethyl-1H-pyrazole-4- carboxamido)-2,3-dihydro-1H-inden- 5-yl)-1,2,4-oxadiazol-5-yl)methyl acetate; N-(5-(5-isopropyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide; N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (1S)-1-(3-(1-(1,3-dimethyl-1H- pyrazole-4-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)ethyl acetate; methyl 3-(1-(1,3-dimethyl-1H- pyrazole-4-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazole-5- carboxylate; N-(5-(5-(hydroxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; N-(5-(5-((S)-1-hydroxyethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-1,2,3-triazole-4- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,2,4-oxadiazole-3- carboxamide; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 4-yl)urea; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrazin-2-yl)urea; 5-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2,4-oxadiazole-3-carboxamide; 4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide; 3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-hydroxyisonicotinamide; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-5-yl)urea; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyridazin-3-yl)urea; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-4-yl)urea; 2-amino-N-(5-(5-(difluoromethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-3- carboxamide; 4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-3-carboxamide; (R)-1,3-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 2-yl)urea; 1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-2-yl)urea; (R)-1,3-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-2,4-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide; (R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-4- methylisoxazole-5-carboxamide (R)-4-methyl-N-(5-(5-(oxetan-3-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-1,2,4-triazole-3- carboxamide; 1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-1,2,4-triazole-3-carboxamide; 1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-1,2,4-triazole-5-carboxamide; N-((R)-5-(5-((S)-1-methoxyethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-4-methylisoxazole-5- carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1,2,4-oxadiazole-5- carboxamide; 3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2,4-oxadiazole-5-carboxamide; N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide; 2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide; (R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide; N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide; 2-methyl-N-(5-(2-methyloxazol-5-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(2-methyloxazol-5- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; 2-methyl-N-(5-(5-methylisoxazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(5-methyloxazol-2- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; 2-methyl-N-(5-(5-methyloxazol-2-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; 2-methyl-N-(5-(2-methyloxazol-4-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(2-methyloxazol-4- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-methyl-N-(5-(2-methyl-2H- tetrazol-5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; 2-methyl-N-(5-(2-methyl-2H-tetrazol- 5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (S)-2-methyl-N-(5-(2-methyl-2H- tetrazol-5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4H-1,2,4-triazole-3-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyl-4H-1,2,4-triazole-3- carboxamide; N-(5-(5-(difluoromethyl)isoxazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-N-(5-(5-(difluoromethyl)isoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; N-(5-(3-(difluoromethyl)isoxazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-N-(5-(3-(difluoromethyl)isoxazol- 5-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-2-methyl-N-(5-(4-methyloxazol-2- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; 2-methyl-N-(5-(4-methyloxazol-2-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide; 1-methyl-N-((1R)-5-(5-(oxetan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2,4-dimethyloxazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-tetrazole-5- carboxamide; (R)-1,3-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1,3-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; (R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; (R)-1-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2H-tetrazole-5- carboxamide; (R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; (R)-1,3-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-1,3-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-4-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide; (R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide; (R)-1,5-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-4-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide; (R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2-methyl-2H- tetrazole-5-carboxamide; (R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide; (R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide; (R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; (R)-1,5-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-2-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-2H-tetrazole-5- carboxamide; (R)-1-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-4-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide; (R)-1-methyl-N-(5-(pyrimidin-2-yl)- 2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(pyridin-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide; (R)-1-methyl-N-(5-(pyrazin-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide; (R)-1-methyl-N-(5-(pyridazin-4-yl)- 2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(thiazol-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide; (R)-1-methyl-N-(5-(5-methylthiazol-2- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(6-methylpyridin- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(5-methylpyridin- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(6-methylpyridin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(4- methylpyrimidin-2-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(2- methylpyrimidin-4-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(4-methylpyridin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(6- methylpyrimidin-4-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(6-methylpyrazin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-1-methyl-N-(5-(5- methylpyridazin-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-1-methyl-N-(5-(6- methylpyridazin-4-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide; (R)-3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; (R)-3-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-1-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-1-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2- methylisonicotinamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1-methyl-1H- pyrazole-5-carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide; (R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide; (R)-4-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-5-methyl-1H- pyrazole-4-carboxamide; (R)-5-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide; (R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide; (R)-1-methyl-N-(5-(5-(1- methylcyclopropyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide; N-((1R)-5-(5-(2,2- dimethylcyclopropyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide; (R)-2-methyl-N-(5-(5-(1- methylcyclopropyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (methoxymethyl)oxazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- ((methylsulfonyl)methyl)oxazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- (oxetan-3-yl)-1H-pyrazole-4- carboxamide; tert-butyl (R)-3-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)carbamoyl)-1H-pyrazol-1- yl)azetidine-1-carboxylate; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-4- carboxamide; methyl (R)-2-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)-1H-pyrazol-1- yl)acetate; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-4- carboxamide; (R)-1-(2-amino-2-oxoethyl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxy-2-methylpropyl)-1H- pyrazole-4-carboxamide; (R)-1-(1-acetylazetidin-3-yl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- (methylsulfonyl)azetidin-3-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- (methylcarbamoyl)azetidin-3-yl)-1H- pyrazole-4-carboxamide; methyl (R)-3-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)-1H-pyrazol-1- yl)azetidine-1-carboxylate; (R)-1-(1-carbamoylazetidin-3-yl)-N- (5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; 5-(5-ethyl-1,2,4-oxadiazol-3-yl)-N-(1- methyl-1H-pyrazol-4-yl)-2,3-dihydro- 1H-indene-1-carboxamide; 5-(5-ethyl-1,2,4-oxadiazol-3-yl)-N-(2- methylpyridin-4-yl)-2,3-dihydro-1H- indene-1-carboxamide; (R)-1-(azetidin-3-yl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; 1-(2,3-dihydroxypropyl)-N-((R)-5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methoxy-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-methyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(methyl-d3)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide; ethyl 2-(3-((R)-1-(1-methyl-1H- pyrazole-5-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)propanoate; ethyl 2-(3-(1-(2-methyloxazole-5- carboxamido)-2,3-dihydro-1H-inden- 5-yl)-1,2,4-oxadiazol-5-yl)propanoate; (R)-2-(4-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1-yl)ethyl acetate; N-((1S,2S)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2-hydroxy-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-4- carboxamide; N-((lR)-5-(5-(1-hydroxypropan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-5- carboxamide; N-((R)-5-(5-((R)-1-hydroxypropan-2- yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro- 1H-inden-1-yl)-1-methyl-1H-pyrazole- 5-carboxamide; N-((R)-5-(5-((S)-1-hydroxypropan-2- yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro- 1H-inden-1-yl)-1-methyl-1H-pyrazole- 5-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide; (R)-2-benzyl-N-(5-(5-isopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; (R)-2-benzyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide; (R)-2-benzyl-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; ethyl 2-(3-((R)-1-(2-methyl-2H- tetrazole-5-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)propanoate; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- (oxetan-3-ylmethyl)-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((3- methyloxetan-3-yl)methyl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((3- fluorooxetan-3-yl)methyl)-1H- pyrazole-4-carboxamide; (R)-1-(2-methoxyethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-4- carboxamide; (R)-1-(2-methoxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide; (R)-1-(2-methoxyethyl)-N-(5-(5- (methyl-d3)-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; N-((1R)-5-(5-(1-hydroxypropan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methyl-2H-tetrazole-5- carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- (methyl-d3)-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- isopropyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide; N-(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- vinyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide; (R)-1-(2,2-dimethoxyethyl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide; 2-(4-(((R)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1- yl)propanoic acid; (R)-2-(4-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1-yl)acetic acid; N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- hydroxypropan-2-yl)-1H-pyrazole-4- carboxamide; N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxypropyl)-1H-pyrazole-4- carboxamide; N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2R)-2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide; N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2S)-2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide; N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2S)-2- hydroxypropyl)pyrazol-4- yl]carboxamide; N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2R)-2- hydroxypropyl)pyrazol-4- yl]carboxamide; 1-(3-{(1R)-1-[(1-methylpyrazol-4- yl)carbonylamino]indan-5-yl}(1,2,4- oxadiazol-5-yl))(1S)ethyl acetate; methyl 2-(3-{(1R)-1-[(1- methylpyrazol-4- yl)carbonylamino]indan-5-yl}-1,2,4- oxadiazol-5-yl)acetate; N-[1R)-5-(5-acetyl(1,2,4-oxadiazol-3- yl))indanyl](1-methylpyrazol-4- yl)carboxamide; N-{(1R)-5-[5-(2-methoxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide; N-[(1R)-5-(5-vinyl(1,2,4-oxadiazol-3- yl))indanyl](1-methylpyrazol-4- yl)carboxamide; 2-(3-{(1R)-1-[(1-methylpyrazol-4- yl)carbonylamino]indan-5-yl}-1,2,4- oxadiazol-5-yl)ethylacetate; N-{(1R)-5-[5-(hydroxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide; N-{(1R)-5-[5-((1R)-1- hydroxyethyl)(1,2,4-oxadiazol-3- yl)]indanyl}(1-methylpyrazol-4- yl)carboxamide; N-{(1R)-5-[5-(methoxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide; N-{(1R)-5-[5-(2-hydroxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide; N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-(2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-7-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide; Ethyl (R)-4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)picolinate; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- fluoro-2-methylisonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methoxyisonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-2-oxo-1,2-dihydropyridine-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-2-oxo-1,2- dihydropyridine-4-carboxamide; N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((R)- 2-hydroxypropyl)-2-oxo-1,2- dihydropyridine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-4-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylisoxazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisoxazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,2- dimethyl-1H-imidazole-5- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylisoxazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide; (R)-1-(2-ethoxyethyl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide; N-((R)-5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-((R)-2-hydroxypropyl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (hydroxymethyl)isonicotinamide; (R)-2-(difluoromethyl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-imidazole-2-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-4-carboxamide; (R)-N-(7-chloro-5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-6-oxo-1,6-dihydropyridine-3- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylthiazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-2-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpicolinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylthiazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-3-methyl-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-3-methyl-1H-pyrazole- 4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- methoxypropyl)-5-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- methoxypropyl)-5-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(3-methoxypropyl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(3-hydroxypropyl)-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-3- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6-oxo- 1,6-dihydropyridine-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6-oxo- 1,6-dihydropyridine-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-5- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-3- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-7-hydroxy-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2-(2- hydroxypropan-2-yl)isonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- hydroxypropyl)-5-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- hydroxypropyl)-3-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (hydroxymethyl)-1-methyl-1H- imidazole-5-carboxamide; (R)-2-(5-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-2-oxopyridin-1(2H)- yl)acetic acid; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,2,5- oxadiazole-3-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-1,2,3-triazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-oxadiazole-2- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-oxadiazole-2- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-thiadiazole-2- carboxamide; (R)-3-chloro-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-1,2,3-triazole-4- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyloxazole-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)nicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylnicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylnicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methylnicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)pyrimidine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpyrimidine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)pyridazine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methyl-1,2,5-oxadiazole-3- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- hydroxyisoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methoxyisoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyloxazole-2-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylpyridazine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- hydroxyoxazole-5-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- (trifluoromethyl)oxazole-5- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylthiazole-2-carboxamide; (R)-1-ethyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-oxo-1,6-dihydropyridine-3- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylpicolinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylpyrimidine-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-2-chloro-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpyridazine-4-carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- (hydroxymethyl)picolinamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- vinylisonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide; (R)-2-ethyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)isonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2- (hydroxymethyl)isonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2- (hydroxymethyl)isonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(hydroxymethyl)picolinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(hydroxymethyl)picolinamide; (R)-4-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide; (R)-4-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-hydroxyisoxazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-5-methyl-1H- pyrazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylthiazole-5-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methoxyisoxazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyloxazole-2-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(trifluoromethyl)oxazole-5- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-methylpyrimidine-4- carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methoxyisonicotinamide; (R)-2-(difluoromethyl)-N-(5-(5- (difluoromethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-3-methyl- 1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-methylpyridazine-4- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methylisoxazole-3- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyl-1,2,5-oxadiazole-3- carboxamide; (R)-3-methoxy-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1- yl)isoxazole- 5-carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl-5- methyl-1H-pyrazole-4-carboxamide; (R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylthiazole-5-carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,3,4-oxadiazole-2- carboxamide; (R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,3,4-oxadiazole-2- carboxamide; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-6-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide; (R)-1,2-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-imidazole-5- carboxamide; (R)-5-methyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)-1,3,4-oxadiazole- 2-carboxamide; (R)-1-(2-hydroxyethyl)-5-methyl- N-(5-(3-methyl-1,2,4-oxadiazol- 5-yl)-2,3-dihydro-1H-inden-1-yl)- 1H-pyrazole-4-carboxamide; (R)-6-methyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)pyridazine-4- carboxamide; (R)-2-(difluoromethyl)-N-(5-(3- methyl-1,2,4-oxadiazol-5-yl)-2,3- dihydro-1H-inden-1- yl)isonicotinamide; (R)-4-acetyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)picolinamide; N-((R)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)- 4-(1-hydroxyethyl)picolinamide; (R)-2-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-(difluoromethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1- yl)isonicotinamide; (R)-2-(difluoromethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide; (R)-4-(difluoromethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1- yl)picolinamide; and (R)-4-(difluoromethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)picolinamide. 30. A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 31. A method of treating heart disease in a subject in need thereof, comprising administering to the subject a compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the heart disease is hypertrophic cardiomyopathy (HCM) or heart failure with preserved ejection fraction (HFpEF). 32. The method of claim 31, wherein the heart disease is hypertrophic cardiomyopathy (HCM). 33. The method of claim 32, wherein the HCM is obstructive or nonobstructive or is associated with a sarcomeric and/or non-sarcomeric mutation. 34. The method of claim 31, wherein the heart disease is heart failure with preserved ejection fraction (HFpEF). 35. A method of inhibiting the cardiac sarcomere, comprising contacting the cardiac sarcomere with a compound of claim 1, or a pharmaceutically acceptable salt thereof. 36. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 37. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 38. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 39. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 40. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 41. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 42. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 43. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is 44. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 45. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 46. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 47. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 48. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 49. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 50. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof. 51. The method of claim 31, wherein the method comprises administering to the subject the compound or a pharmaceutically acceptable salt thereof.