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Last Updated: December 16, 2025

Claims for Patent: 10,806,733

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Summary for Patent: 10,806,733

Title:	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
Abstract:	Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Inventor(s):	Brian Metcalf, Chihyuan Chuang
Assignee:	Global Blood Therapeutics Inc
Application Number:	US16/017,248
Patent Claims:	1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is a pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, each of which is substituted with one Ra; R2, R3, and R4 are each hydrogen; Y is CH2; X is O or CH2; R5 is halo or OH; R6 and R7 together form oxo; Ra is heteroaryl substituted with one to three Rc; and each Rc is independently selected from the group consisting of C1-8alkyl and haloC1-8 alkyl. 2. The compound of claim 1, wherein X is 0. 3. The compound of claim 1, wherein R5 is OH. 4. The compound of claim 1, wherein Ra is substituted with one Rc, and Rc is C1-6alkyl or haloC1-6alkyl. 5. The compound of claim 2, wherein: Q is pyridin-3-yl substituted with one Ra. 6. The compound of claim 5, wherein Ra is heteroaryl having two nitrogen ring atoms. 7. The compound of claim 6, wherein Ra is substituted with one Rc, and Rc is C1-6alkyl or haloC1-6alkyl.

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