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Last Updated: May 2, 2024

Claims for Patent: 10,722,502

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Summary for Patent: 10,722,502

Title:	Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde
Abstract:	Disclosed are crystalline free base an solvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde (or Compound 1), such as the free base Form I, Form II and Material N. Also disclosed are crystalline free base solvates of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde (or Compound 1).
Inventor(s):	Li; Zhe (San Diego, CA), Parent; Stephan D. (South San Francisco, CA), Houston; Travis (South San Francisco, CA)
Assignee:	Global Blood Therapeutics, Inc. (South San Francisco, CA)
Application Number:	16/163,942
Patent Claims:	1. A composition comprising a crystalline ansolvate of Compound 1: ##STR00011## characterized by X-ray powder diffraction peaks (Cu K.alpha. radiation) at 13.37 .degree. , 14.37 .degree. , 19.95.degree. and 23.92 .degree.2 .theta. (each .+-.0.2 .degree.2.theta.), wherein the composition is substantially free of other ansolvate polymorphs of Compound 1. 2. The composition of claim 1, wherein the crystalline ansolvate of Compound 1 is characterized by an X-ray powder diffraction pattern (Cu K.alpha. radiation) substantially similar to that of FIG. 5. 3. The composition of claim 1, wherein the crystalline ansolvate of Compound 1 is characterized by an endothermic peak at 97 .+-. 2 .degree. C. as measured by differential scanning calorimetry.

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