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Last Updated: December 31, 2025

Claims for Patent: 10,716,793

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Summary for Patent: 10,716,793

Title:	Treprostinil administration by inhalation
Abstract:	Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
Inventor(s):	Horst Olschewski, Robert Roscigno, Lewis J. Rubin, Thomas Schmehl, Werner Seeger, Carl Sterritt, Robert Voswinckel
Assignee:	United Therapeutics Corp
Application Number:	US16/778,662
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,716,793
Patent Claims:	1. A method of treating pulmonary hypertension comprising administering by inhalation to a human suffering from pulmonary hypertension a therapeutically effective single event dose of a formulation comprising treprostinil or a pharmaceutically acceptable salt thereof with an inhalation device, wherein the therapeutically effective single event dose comprises from 15 micrograms to 90 micrograms of treprostinil or a pharmaceutically acceptable salt thereof delivered in 1 to 3 breaths. 2. The method of claim 1, wherein the inhalation device is a soft mist inhaler. 3. The method of claim 1, wherein the inhalation device is a pulsed ultrasonic nebulizer. 4. The method of claim 1, wherein the inhalation device is a dry powder inhaler. 5. The method of claim 1, wherein the inhalation device is a pressurized metered dose inhaler. 6. The method of claim 4, wherein the formulation is a powder. 7. The method of claim 6, wherein the powder comprises particles less than 5 micrometers in diameter. 8. The method of claim 1, wherein the formulation contains no metacresol.

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