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Last Updated: December 16, 2025

Claims for Patent: 10,537,520

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Summary for Patent: 10,537,520

Title:	Stable liquid formulations of melphalan
Abstract:	The present invention relates to stable, liquid parenteral formulations of Melphalan or pharmaceutically acceptable salts thereof. Further this invention also describes process of preparing such formulations.
Inventor(s):	Kocherlakota CHANDRASHEKHAR, Banda NAGARAJU
Assignee:	Leiutis Pharmaceutials LLP
Application Number:	US15/739,034
Patent Claims:	1. A stable, liquid parenteral formulation consisting of (i) melphalan hydrochloride 1 to 30% (ii) dimethylacetamide or polyethylene glycol 20 to 95% (iii) ethanol 0 to 50% (iv) propylene glycol. 5 to 50% (v) monothioglycerol 0.05 to 5% by weight of the composition. 2. The formulation of claim 1 wherein the pH of the formulation is between 2 to 5. 3. A stable, liquid parenteral formulation consisting of (i) melphalan hydrochloride 1 to 30% (ii) polyethylene glycol 20 to 85% (iii) ethanol 0 to 50% (iv) propylene glycol 5 to 50% (v) monothioglycerol 0.05 to 5% by weight of the composition. 4. The formulation of claim 3 wherein the pH of the formulation is between 2 to 5.

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