Claims for Patent: 10,463,668

Summary for Patent: 10,463,668

Title:	Methods of treating and preventing graft versus host disease
Abstract:	Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors. The methods include administering to an individual in need thereof an ACK inhibitor such as ibrutinib for treating and preventing graft versus host disease.
Inventor(s):	John C. Byrd, Jason A. Dubovsky, Natarajan Muthusamy, Amy J. Johnson, David Miklos
Assignee:	Pharmacyclics LLC
Application Number:	US15/586,058
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,463,668
Patent Claims:	1. A method of treating refractory chronic graft versus host disease (GVHD) comprising orally administering 420 mg of ibrutinib once per day to an adult human patient having chronic GVHD refractory to systemic therapy, wherein the adult human patient achieves a complete response (CR), wherein the CR is a complete resolution of symptoms attributable to chronic GVHD. 2. The method of claim 1, wherein the adult human had a hematopoietic cell transplantation. 3. The method of claim 1, wherein the refractory chronic GVHD is steroid-resistant chronic GVHD. 4. The method of claim 1, wherein the refractory chronic GVHD is cyclosporin-resistant chronic GVHD.