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Last Updated: October 23, 2020

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Claims for Patent: 10,456,414

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Summary for Patent: 10,456,414
Title:Methods for treating HCV
Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
Inventor(s): Delaney, IV; William E. (Foster City, CA), Link; John O. (San Francisco, CA), Mo; Hongmei (Palo Alto, CA), Oldach; David W. (Chapel Hill, NC), Ray; Adrian S. (Redwood City, CA), Watkins; William J. (Saratoga, CA), Yang; Cheng Yong (Foster City, CA)
Assignee: Gilead Pharmasset LLC (Foster City, CA)
Application Number:15/400,088
Patent Claims: 1. A composition comprising compound 10 having the structure: ##STR00075## or a pharmaceutically acceptable salt thereof, and compound 6 having the structure: ##STR00076## or a pharmaceutically acceptable salt thereof.

2. The composition of claim 1, further comprising a pharmaceutically acceptable diluent or carrier.

3. The composition of claim 1, formulated as a unit dosage form for once daily administration.

4. The composition of claim 1, formulated for oral administration.

5. The composition of claim 1, further comprising ribavirin.

6. A tablet comprising compound 10 having the structure: ##STR00077## or a pharmaceutically acceptable salt thereof, and compound 6 having the structure: ##STR00078## or a pharmaceutically acceptable salt thereof.

7. A composition consisting of two active ingredients and one or more pharmaceutically acceptable diluent or carrier, wherein the two active ingredients are compound 10 or a pharmaceutically acceptable salt thereof, and compound 6 or a pharmaceutically acceptable salt thereof, and wherein compound 10 has the structure: ##STR00079## and compound 6 has the structure: ##STR00080##

8. The composition of claim 7, formulated as a unit dosage form for once daily administration.

9. The composition of claim 8, wherein the unit dose has 30 mg to 90 mg of compound 6 or a pharmaceutically acceptable salt thereof, and 10 mg to 1000 mg of compound 10 or a pharmaceutically acceptable salt thereof.

10. The composition of claim 8, wherein the unit dose has 90 mg of compound 6 or a pharmaceutically acceptable salt thereof, and 10 mg to 1000 mg of compound 10 or a pharmaceutically acceptable salt thereof.

11. The composition of claim 7, formulated for oral administration.

12. The composition of claim 7, formulated as a tablet for oral administration.

13. The composition of claim 8, formulated as a tablet for oral administration.

14. The composition of claim 9, formulated as a tablet for oral administration.

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