Claims for Patent: 10,398,681

Summary for Patent: 10,398,681

Title:	Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
Abstract:	Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
Inventor(s):	Isabella A. Graef, Mamoun M. Alhamadsheh
Assignee:	Leland Stanford Junior University
Application Number:	US15/883,750
Patent Claims:	1. A kit comprising a unit dose of Compound VIIa: wherein Ra is selected from the group consisting of OH, CHO, COOH, CONH2, CONH(OH), COOR6, and CONHR6; and R6 is straight or branched alkyl of 1-3 carbon atoms; or a pharmaceutically acceptable salt thereof. 2. The kit of claim 1, further comprising a package insert describing the use of Compound VIIa. 3. The kit of claim 1, wherein Ra is selected from the group consisting of COOH CONH2, CONH(OH), COOR6, and CONHR6. 4. The kit of claim 1, wherein Compound VIIa has a structure of Compound VIIc or a pharmaceutically acceptable salt thereof.