Claims for Patent: 10,364,238

Summary for Patent: 10,364,238

Title:	N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
Abstract:	The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
Inventor(s):	Rebecca Louise Davie, Hannah Joy Edwards, David Michael Evans, Simon Teanby Hodgson
Assignee:	Kalvista Pharmaceuticals Ltd
Application Number:	US15/527,923
Patent Claims:	1. A compound that is: or a pharmaceutically acceptable salt or solvate thereof. 2. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 3. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 4. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 5. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 6. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 7. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 8. The compound of claim 1 that is: or a pharmaceutically acceptable salt or solvate thereof. 9. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 10. A pharmaceutical composition comprising a compound of claim 2, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 11. A pharmaceutical composition comprising a compound of claim 3, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 12. A pharmaceutical composition comprising a compound of claim 4, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 13. A pharmaceutical composition comprising a compound of claim 5, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 14. A pharmaceutical composition comprising a compound of claim 6, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 15. A pharmaceutical composition comprising a compound of claim 7, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 16. A pharmaceutical composition comprising a compound of claim 8, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.