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Last Updated: December 16, 2025

Claims for Patent: 10,287,258

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Summary for Patent: 10,287,258

Title:	Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Abstract:	The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
Inventor(s):	Hans Roland LONN, Stephen Connolly, Steven Swallow, Staffan PO KARLSSON, Carl-Johan Aurell, John Fritiof PONTÉN, Kevin James Doyle, Amanda Jane VAN DE POËL, Graham Peter Jones, David Wyn WATSON, Jaqueline Anne MACRITCHIE, Nicholas John Palmer
Assignee:	Biofocus DPI Ltd , AstraZeneca AB
Application Number:	US15/708,634
Patent Claims:	1. A compound of formula (I) wherein R1 is X is selected from O, S or CF2; R6 is selected from C1-3alkyl, wherein said C1-3alkyl is optionally substituted by 1, 2 or 3 F; R7 is selected from hydrogen, F, Cl or CH3; or a pharmaceutically-acceptable salt thereof. 2. A pharmaceutical composition comprising a compound of formula (I) as claimed in claim 1 and a pharmaceutically acceptable adjuvant, diluent or carrier. 3. A method of treating an obstructive disease of the airway, which comprises administering to the patient a therapeutically effective amount of a compound of formula (I) as claimed in claim 1. 4. A method of treating asthma or chronic obstructive pulmonary disease in a patient suffering from said disease, which comprises administering to the patient a therapeutically effective amount of a compound of formula (I) as claimed in claim 1. 5. The method of claim 3, wherein administering comprises oral administration. 6. The method of claim 4, wherein administering comprises oral administration.

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