Claims for Patent: 10,252,010

Summary for Patent: 10,252,010

Title:	Nasal delivery devices
Abstract:	A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.
Inventor(s):	Djupesland; Per Gisle (Oslo, NO), Sheldrake; Colin David (Wiltshire, GB)
Assignee:	OptiNose AS (Oslo, NO)
Application Number:	14/721,097
Patent Claims:	1. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a mouthpiece through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece for fitting to a nostril of the subject, the nosepiece including a nozzle through which the substance is in use delivered to the nasal airway; a manually-actuatable substance supply unit for delivering the substance through the nozzle of the nosepiece; and a body member which receives the manually-actuatable substance supply unit, wherein the body member includes an inlet which is in fluid communication with the mouthpiece and an outlet which is in fluid communication with the nosepiece; wherein the manually-actuatable substance supply unit comprises a body part which is movable from a first, rest position to a second, actuated position on manual actuation of the manually-actuatable substance supply unit, and the inlet of the body member is opened when the body part of the manually-actuatable substance supply unit is moved to the actuated position, thereby providing for an air flow through the nosepiece simultaneously with manual actuation of the manually-actuatable substance supply unit. 2. The delivery device of claim 1, further comprising: a valve assembly which is fluidly connected to the mouthpiece and the nosepiece, and movable between a closed configuration in which there is no fluid communication path between the mouthpiece and the nosepiece and an open configuration on actuation of the manually-actuatable substance supply unit, so as to provide for an air flow through the nosepiece on actuation of the manually-actuatable substance supply unit. 3. The delivery device of claim 1, further comprising: a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is adapted to be delivered through the nosepiece. 4. The delivery device of claim 1, wherein the manually-actuatable substance supply unit is configured to be manually depressed by the subject. 5. The delivery device of claim 1, further comprising: a loading mechanism which is primed with a loading force and manually actuated to apply the loading force to the manually-actuatable substance supply unit and actuate the manually-actuatable substance supply unit. 6. The delivery device of claim 1, wherein the manually-actuatable substance supply unit comprises a substance-containing chamber which provides a volume of the substance for delivery by the delivery device. 7. The delivery device of claim 6, wherein the manually-actuatable substance supply unit further comprises a piston member which is movable relative to the substance-containing chamber to deliver a dose of the substance from the substance-containing chamber. 8. The delivery device of claim 7, wherein the piston member is movable between a plurality of respective positions, so as to deliver a metered dose of the substance with each advance of the piston member between respective ones of the positions. 9. The delivery device of claim 7, wherein the piston member is movable relative to the body member and one of the piston member and the body member includes a track which includes track sections which define respective positions, and the other of the piston member and the body member includes a follower which is located in the track and moved in succession to each of the respective positions on actuation of the piston member. 10. The delivery device of claim 7, wherein the manually-actuatable substance supply unit is a duo-dose pump unit, with the piston member being movable to two separate positions. 11. The delivery device of claim 6, wherein the substance-containing chamber comprises first and second chambers which each separately contain a respective substance component and provide for re-constitution of the substance components to provide re-constituted substance for delivery by the delivery device. 12. The delivery device of claim 11, wherein the substance-containing chamber further comprises a frangible member which normally separates the first and second chambers and when ruptured provides for the re-constitution of the substance components to provide the re-constituted substance for delivery by the delivery device. 13. The delivery device of claim 12, wherein the delivery device includes a rupturing element which is configured to rupture the frangible member on fitting the substance-containing chamber to a housing of the delivery device. 14. The delivery device of claim 1, wherein the nosepiece includes a sealing member which is adapted to provide for a tight sealing fit with the nostril of the subject. 15. The delivery device of claim 1, further comprising: a flow regulator which is configured, with actuating movement of the manually-actuatable substance supply unit, to regulate flow characteristics, of an exhalation air flow as delivered through the nosepiece. 16. The delivery device of claim 15, where the flow characteristics comprise one or more of flow rate, flow profile and flow duration. 17. The delivery device of claim 15, wherein the flow regulator includes an aperture into which extends a movable part of the manually-actuatable substance supply unit, and, with actuating movement of the manually-actuatable substance supply unit, the effective area of a flow channel to the nosepiece has a predetermined profile over the actuating movement of the manually-actuatable substance supply unit. 18. The delivery device of claim 1, wherein the manually-actuatable substance supply unit provides for the delivery of a powder substance or a liquid substance. 19. The delivery device of claim 18, wherein the substance is delivered as an aerosol or a jet.