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Last Updated: June 21, 2024

Claims for Patent: 10,238,640


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Summary for Patent: 10,238,640
Title:Pharmaceutical suspension composition
Abstract: An aqueous oral liquid pharmaceutical composition system with reduced propensity for agglomeration and phase separation which is particularly amendable to the suspension of one or more pharmaceutical actives that are substantially insoluble in water. The oral liquid pharmaceutical composition may further comprise pharmaceutical actives that are soluble in water and dissolve in the aqueous medium. In the composition of the invention both suspended and any dissolved active agents are distributed homogeneously.
Inventor(s): Dickerson; Jay (Midlothian, VA), Mark; William (Glen Allen, VA), Trimmer; Annabelle (Manakin-Sabot, VA), Jaeger; David (Chester, VA), Alley; Amanda (Midlothian, VA)
Assignee: Wyeth LLC (New York, NY)
Application Number:15/349,101
Patent Claims: 1. A thixotropic oral liquid pharmaceutical composition consisting of 0.2 g/100 mL xanthan gum; 1.5 g/100 mL microcrystalline cellulose/carboxymethylcellulose sodium; about 2 g/100 mL ibuprofen; about 28.8 g/100 mL glycerin; 20 g/100 mL sorbitol solution 70%; about 0.2 g/100 mL sucralose; 0.3 g/100 mL polysorbate; about 0.02 g/100 mL chlorpheniramine maleate; about 0.3 g/100 mL pseudoephedrine; about 0.55 g/100 mL sodium citrate; about 0.25 g/100 mL sodium benzoate; about 0.05 g/100 mL edetate disodium; about 0.75 g/100 mL citric acid; flavoring agent; coloring agent; and water.

2. A thixotropic oral liquid pharmaceutical composition consisting of about 2 g/100 mL ibuprofen; 0.2 g/100 mL xanthan gum; 1.5 g/100 mL microcrystalline cellulose/carboxymethylcellulose sodium; about 28.8 g/100 mL glycerin; 20 g/100 mL sorbitol solution 70%; about 0.55 g/100 mL sodium citrate; about 0.05 g/100 mL edetate disodium; about 0.75 g/100 mL citric acid; 0.3 g/100 mL polysorbate; about 0.25 g/100 mL sodium benzoate; about 0.2 g sucralose/100 mL; flavoring agent; and water.

3. A thixotropic oral liquid pharmaceutical composition consisting of 0.2 g/100 mL xanthan gum; about 1.5 g/100 mL microcrystalline cellulose/carboxymethylcellulose sodium; about 1 g/100 mL to about 3 g/100 mL ibuprofen; 0.3 g/100 mL polysorbate; about 0.25 g/100 mL sodium benzoate; about 0.01 g/100 mL to about 0.40 g/100 mL diphenhydramine; about 28.8 g/100 mL glycerin; about 20 g/100 mL sorbitol solution 70%; sucralose; about 0.55 g/100 mL sodium citrate; about 0.05 g/100 mL edetate disodium; about 0.75 g/100 mL citric acid; flavoring agent; and water.

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