Claims for Patent: 10,149,843

Summary for Patent: 10,149,843

Title:	Pharmaceutical compositions and methods of using the same
Abstract:	Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
Inventor(s):	Moshal; Jeffrey M. (Allentown, PA), Libman; Michael (Allentown, PA)
Assignee:	GNEUS LIFESCINECES INC. (Allentown, PA)
Application Number:	15/427,011
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,149,843
Patent Claims:	1. A method for induction of local anesthesia prior to performing a diagnostic procedure on, through, or adjacent a mucous membrane of the nasal cavities of a patient comprising: soaking a plurality of absorbent articles with an aqueous solution comprising, by weight, about 4% cocaine hydrochloride, greater than 0 to less than about 0.150% citric acid, and about 0.07% to about 0.20% sodium benzoate; and contacting the absorbent articles with the mucous membrane in a nasal cavity against a septum of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, provided that the method results in an absorptivity factor for cocaine in the patient ranging from about 0.640 h.sup.-1 to about 0.687 h.sup.-1. 2. The method of claim 1, wherein the diagnostic procedure comprises nasal endoscopy. 3. The method of claim 2, wherein the diagnostic procedure comprises nasal endoscopy with debridement. 4. The method of claim 1, wherein the diagnostic procedure comprises laryngoscopy. 5. The method of claim 4, wherein the diagnostic procedure comprises nasal laryngoscopy. 6. The method of claim 4, wherein the diagnostic procedure comprises nasopharyngeal laryngoscopy. 7. The method of claim 1, wherein the diagnostic procedure comprises transnasal esophagoscopy. 8. The method of claim 1, wherein the diagnostic procedure comprises nasal stroboscopy. 9. A method of administering a topical localized anesthetic composition to a patient comprising: soaking a plurality of absorbent articles with an aqueous solution comprising, by weight, about 4% cocaine hydrochloride, greater than 0 to less than about 0.150% citric acid, and about 0.07% to about 0.20% sodium benzoate; and contacting the absorbent articles with a nasal mucous membrane in a nasal cavity against a septum of the patient for up to about 20 minutes, provided that the method results in an absorptivity factor for cocaine in the patient ranging from about 0.640 h.sup.-1 to about 0.687 h.sup.-1. 10. The method of claim 9, wherein the absorbent articles comprise pledgets. 11. The method of claim 10, wherein the pledgets comprise four pledgets. 12. The method of claim 11, wherein the four pledgets are soaked in the pharmaceutical composition for at least ten minutes prior to contacting the nasal mucous membrane. 13. The method of claim 10, wherein the pledgets comprise cottonoid pledgets. 14. The method of claim 13, wherein each of the cottonoid pledgets retains up to 90% of the pharmaceutical composition when removed from contact with the nasal mucous membrane.