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Last Updated: March 28, 2024

Claims for Patent: 10,124,079


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Summary for Patent: 10,124,079
Title:Imaging of metastatic or recurrent cancer
Abstract: The present disclosure relates to methods of administering [.sup.18F]-FACBC. The present disclosure also relates to use of [.sup.18F]-FACBC in methods for imaging, diagnosing and monitoring metastasis or recurrence of cancer.
Inventor(s): Miller; Matthew (Oxford, GB), Gauden; David (Oxford, GB), Schuster; David (Atlanta, GA), Fanti; Stefano (Bologna, IT), Nanni; Cristina (Bologna, IT), Zanoni; Lucia (Bologna, IT), Willoch; Frode (Oslo, NO), Bogsrud; Trond Velde (Oslo, NO), Bach-Gansmo; Tore (Oslo, NO), Musto; Alessandra (Bologna, IT)
Assignee: Blue Earth Diagnostics Limited (Oxford, GB)
Application Number:14/983,746
Patent Claims: 1. A method of administering anti-1-amino-3-.sup.18F-fluorocyclobutane-1-carboxylic acid ([.sup.18F]-FACBC) to a subject comprising the steps of: a) injecting a detectable amount of [.sup.18F]-FACBC into a right arm of the subject, wherein said arm is positioned adjacent to the subject's torso, wherein the subject has consumed no food or drink including water for at least 4 hours prior to the injection; b) raising said arm into an overhead position; and c) acquiring a positron emission tomography (PET) scan image of at least a pelvic region of the subject; wherein said arm remains in the overhead position during the PET scan, and wherein the PET scan starts about 3 to 5 minutes after [.sup.18F]-FACBC has been injected.

2. The method of claim 1, wherein the PET scan starts 4 minutes after [.sup.18F]-FACBC is injected.

3. The method of claim 1, wherein the PET scan is completed between 3 to 30 minutes after the injection of [.sup.18F]-FACBC.

4. The method of claim 1, wherein [.sup.18F]-FACBC is injected over a time period of about 1 to 2 minutes.

5. The method of claim 1, wherein [.sup.18F]-FACBC is injected over a time period of 1 minute.

6. The method of claim 1, wherein step b) includes raising both arms of the subject into an overhead position.

7. The method of claim 1, wherein step a) includes injecting a dosage of [.sup.18F]-FACBC between 250 MBq and 500 MBq into the right arm of the subject.

8. The method of claim 1, wherein step a) includes injecting the [.sup.18F]-FACBC into the right arm of the subject while the subject is lying down in a horizontal position, and step b) includes raising the right arm into the overhead position less than about 5 seconds after injecting the [.sup.18F]-FACBC.

9. The method of claim 1, wherein PET and magnetic resonance imaging (MRI) scan images or PET and X-ray computed tomography (CT) scan images are acquired in step c).

10. The method of claim 9, wherein the PET and MM scan images or the PET and CT scan images are acquired using a combined PET-MM system or a combined PET-CT system, respectively.

11. The method of claim 1, wherein acquiring the PET scan image in step c) includes scanning performed in at least 4 bed positions according to the following parameters: scanning starts 3 to 5 minutes after the injection of [.sup.18F]-FACBC; scanning occurs in a direction of feet to head of the subject; for the first 2 or 3 bed positions, the scanning time per bed position is 4 to 5 minutes; and for the subsequent bed positions, the scanning time per bed position is 2 to 3 minutes.

12. The method of claim 11, wherein scanning starts at a proximal thigh of the patient.

13. A method of detecting recurrent prostate tumours or metastatic tumours in a subject, comprising the steps of: a) injecting a detectable amount of anti-1-amino-3-.sup.18F-fluorocyclobutane-1-carboxylic acid ([.sup.18F]-FACBC) into a right arm of the subject, wherein the subject has fasted from food and water for at least 4 hours prior to the injection, and wherein said arm is positioned adjacent to the subject's torso; b) raising said arm into an overhead position; and c) acquiring a scan image of at least a pelvic region of the subject on a combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanner or a combined PET and X-ray computed tomography (CT) scanner to obtain conjoint PET and MM images or conjoint PET and CT images, respectively; wherein said arm remains in the overhead position during the PET/MRI or PET/CT scan, and wherein the PET/MRI or PET/CT scan starts about 3 to 5 minutes after the [.sup.18F]-FACBC has been injected.

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