Claims for Patent: 10,071,066

Summary for Patent: 10,071,066

Title:	Method of treating cancer using selective estrogen receptor modulators
Abstract:	Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.
Inventor(s):	Wardell Suzanne E., Nelson Erik R., McDonnell Donald P.
Assignee:	Duke University
Application Number:	US15214187
Patent Claims:	2. The method of claim 1 , wherein the estrogen receptor positive breast cancer is de novo resistant to the estrogen receptor modulator.3. The method of claim 1 , wherein the resistance to the estrogen receptor modulator is acquired.4. The method of claim 1 , wherein the estrogen receptor modulator is a selective estrogen receptor modulator (SERM).5. The method of claim 4 , wherein the SERM is tamoxifen claim 4 , idoxifene claim 4 , raloxifene or ICI 182 claim 4 ,780.6. The method of claim 1 , wherein an effective amount of the composition is administered.7. The method of claim 1 , wherein the effective amount comprises a high dosage.8. The method of claim 7 , wherein the high dosage is more than about 20 mg/kg.9. The method of claim 1 , wherein the composition is administered by oral administration claim 1 , intravenous administration claim 1 , intradermal injection claim 1 , intramuscular injection or subcutaneous injection.10. The method of claim 1 , further comprising administering an effective amount of at least one compound selected from the group consisting of a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6 inhibitor) claim 1 , an antiestrogen claim 1 , a ligand of retinoic acid or retinoxic X receptor claim 1 , an antiprogestin claim 1 , an antiandrogen claim 1 , vitamin D or metabolite thereof claim 1 , a farnesyl transferase inhibitor claim 1 , a PPARα or gamma agonist and a MAP kinase inhibitor.