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Claims for Patent: 10,039,754

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Summary for Patent: 10,039,754
Title:Anti-viral compounds
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
Inventor(s): Bellizzi; Mary E. (Missoula, MT), Betebenner; David A. (Grayslake, IL), Califano; Jean-Christophe C. (Whitefish Bay, WI), Carroll; William A. (Evanston, IL), Caspi; Daniel D. (Evanston, IL), DeGoey; David A. (Salem, WI), Donner; Pamela L. (Mundelein, IL), Flentge; Charles A. (Pittsburgh, PA), Gao; Yi (Vernon Hills, IL), Hutchins; Charles W. (Green Oaks, IL), Hutchinson; Douglas K. (Newton, CT), Jinkerson; Tammie K. (Pleasant Prairie, WI), Kati; Warren M. (Gurnee, IL), Keddy; Ryan G. (Beach Park, CA), Krueger; Allan C. (Gurnee, IL), Li; Wenke (Gurnee, IL), Liu; Dachun (Vernon Hills, IL), Maring; Clarence J. (Palatine, IL), Matulenko; Mark A. (Libertyville, IL), Motter; Christopher E. (Oak Creek, WI), Nelson; Lissa T. (Highland Park, IL), Patel; Sachin V. (Round Lake, IL), Pratt; John K. (Kenosha, WI), Randolph; John T. (Libertyville, IL), Rockway; Todd W. (Grayslake, IL), Sarris; Kathy (Mundelein, IL), Tufano; Michael D. (Chicago, IL), Wagaw; Seble H. (Lake Bluff, IL), Wagner; Rolf (Antioch, IL), Woller; Kevin R. (Antioch, IL)
Assignee: AbbVie Inc. (North Chicago, IL)
Application Number:15/431,069
Patent Claims: 1. A method of treating hepatitis C virus (HCV) infection, comprising administering an effective amount of a compound having Formula I or a pharmaceutically acceptable salt thereof, and another anti-HCV agent, to an HCV patient in need thereof, ##STR00967## wherein: X is C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, and is optionally substituted with one or more R.sub.A or R.sub.F; L.sub.1 and L.sub.2 are each independently selected from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; L.sub.3 is bond or -L.sub.S-K-L.sub.S'-, wherein K is selected from bond, --O--, --S--, --N(R.sub.B)--, --C(O)--, --S(O).sub.2--, --S(O)--, --OS(O)--, --OS(O).sub.2--, --S(O).sub.2O--, --S(O)O--, --C(O)O--, --OC(O)--, --OC(O)--, --C(O)N(R.sub.B)--, --N(R.sub.B)C(O)--, --N(R.sub.B)C(O)O--, --OC(O)N(R.sub.B)--, --N(R.sub.B)S(O)--, --N(R.sub.B)S(O).sub.2--, --S(O)N(R.sub.B)--, --S(O).sub.2N(R.sub.B)--, --C(O)N(R.sub.B)C(O)--, --N(R.sub.B)C(O)N(R.sub.B')--, --N(R.sub.B)SO.sub.2N(R.sub.B')--, or --N(R.sub.B)S(O)N(R.sub.B')--; A and B are each independently 3- to 12-membered heterocycle, and are each independently optionally substituted with one or more R.sub.A; D is C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, and is optionally substituted with one or more R.sub.A; or D is C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle which is substituted with J and optionally substituted with one or more R.sub.A, where J is C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle and is optionally substituted with one or more R.sub.A, or J is --SF.sub.5; or D is hydrogen or R.sub.A; Y is selected from -T'-C(R.sub.1R.sub.2)N(R.sub.5)-T-R.sub.D, -T'-C(R.sub.3R.sub.4)C(R.sub.6R.sub.7)-T-R.sub.D, -L.sub.K-T-R.sub.D, or -L.sub.K-E; R.sub.1 and R.sub.2 are each independently R.sub.C, and R.sub.5 is R.sub.B; or R.sub.1 is R.sub.C, and R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; R.sub.3, R.sub.4, R.sub.6, and R.sub.7 are each independently R.sub.C; or R.sub.3 and R.sub.6 are each independently R.sub.C, and R.sub.4 and R.sub.7, taken together with the atoms to which they are attached, form a 3- to 12-membered carbocycle or heterocycle which is optionally substituted with one or more R.sub.A; Z is selected from -T'-C(R.sub.8R.sub.9)N(R.sub.12)-T-R.sub.D, -T'-C(R.sub.10R.sub.11)C(R.sub.13R.sub.14)-T-R.sub.D, -L.sub.K-T-R.sub.D, or -L.sub.K-E; R.sub.8 and R.sub.9 are each independently R.sub.C, and R.sub.12 is R.sub.B; or R.sub.8 is R.sub.C, and R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; R.sub.10, R.sub.11, R.sub.13, and R.sub.14 are each independently R.sub.C; or R.sub.10 and R.sub.13 are each independently R.sub.C, and R and R.sub.14, taken together with the atoms to which they are attached, form a 3- to 12-membered carbocycle or heterocycle which is optionally substituted with one or more R.sub.A; T and T' are each independently selected at each occurrence from bond, -L.sub.S-, -L.sub.S-M-L.sub.S'-, or -L.sub.S-M-L.sub.S'-M'-L.sub.S''-, wherein M and M' are each independently selected at each occurrence from bond, --O--, --S--, --N(R.sub.B)--, --C(O)--, --S(O).sub.2--, --S(O)--, --OS(O)--, --OS(O).sub.2--, --S(O).sub.2O--, --S(O)O--, --C(O)O--, --OC(O)--, --OC(O)O--, --C(O)N(R.sub.B)--, --N(R.sub.B)C(O)--, --N(R.sub.B)C(O)O--, --OC(O)N(R.sub.B)--, --N(R.sub.B)S(O)--, --N(R.sub.B)S(O).sub.2--, --S(O)N(R.sub.B)--, --S(O).sub.2N(R.sub.B)--, --C(O)N(R.sub.B)C(O)--, --N(R.sub.B)C(O)N(R.sub.B')--, --N(R.sub.B)SO.sub.2N(R.sub.B')--, --N(R.sub.B)S(O)N(R.sub.B')--, C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, and wherein said C.sub.3-C.sub.12carbocycle and 3- to 12-membered heterocycle are each independently optionally substituted at each occurrence with one or more R.sub.A; L.sub.K is independently selected at each occurrence from bond, -L.sub.S-N(R.sub.B)C(O)-L.sub.S'- or -L.sub.S-C(O)N(R.sub.B)-L.sub.S'-; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; or C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more R.sub.A; E is independently selected at each occurrence from C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, and is independently optionally substituted at each occurrence with one or more R.sub.A; R.sub.D is each independently selected at each occurrence from hydrogen or R.sub.A; R.sub.A is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -L.sub.S-R.sub.E, wherein two adjacent R.sub.A, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; R.sub.B and R.sub.B' are each independently selected at each occurrence from hydrogen; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.B or R.sub.B' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.C is independently selected at each occurrence from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.C is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.E is independently selected at each occurrence from --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S'), --N(R.sub.S)C(O)R.sub.S', --N(R.sub.S)C(O)N(R.sub.S'R.sub.S''), --N(R.sub.S)SO.sub.2R.sub.S', --SO.sub.2N(R.sub.SR.sub.S'), --N(R.sub.S)SO.sub.2N(R.sub.S'R.sub.S''), --N(R.sub.S)S(O)N(R.sub.S'R.sub.S''), --OS(O)--R.sub.S, --OS(O).sub.2--R.sub.S, --S(O).sub.2OR.sub.S, --S(O)OR.sub.S, --OC(O)OR.sub.S, --N(R.sub.S)C(O)OR.sub.S', --OC(O)N(R.sub.SR.sub.S'), --N(R.sub.S)S(O)--R.sub.S', --S(O)N(R.sub.SR.sub.S'), --P(O)(OR.sub.S).sub.2, or --C(O)N(R.sub.S)C(O)--R.sub.S'; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl, C.sub.2-C.sub.6haloalkynyl, C(O)OR.sub.S, or --N(R.sub.SR.sub.S'); R.sub.F is independently selected at each occurrence from C.sub.1-C.sub.10alkyl, C.sub.2-C.sub.10alkenyl or C.sub.2-C.sub.10alkynyl, each of which contains 0, 1, 2, 3, 4 or 5 heteroatoms selected from O, S or N and is optionally substituted with one or more R.sub.L; or --(R.sub.X--R.sub.Y).sub.Q--(R.sub.X--R.sub.Y'), wherein Q is 0, 1, 2, 3 or 4, and each R.sub.X is independently O, S or N(R.sub.B), wherein each R.sub.Y is independently C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene each of which is independently optionally substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano, and wherein each R.sub.Y' is independently C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl each of which is independently optionally substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; R.sub.L is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S') or --N(R.sub.S)C(O)R.sub.S'; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; wherein two adjacent R.sub.L, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; L.sub.S, L.sub.S' and L.sub.S'' are each independently selected at each occurrence from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; and R.sub.S, R.sub.S' and R.sub.S'' are each independently selected at each occurrence from hydrogen; C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, --O--C.sub.1-C.sub.6alkyl, --O--C.sub.1-C.sub.6alkylene-O--C.sub.1-C.sub.6alkyl, or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.S, R.sub.S' or R.sub.S' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl.

2. A method of treating HCV infection, comprising administering an effective amount of a compound of Formula I.sub.B or a pharmaceutically acceptable salt thereof, and another anti-HCV agent, to an HCV patient in need thereof, ##STR00968## wherein: R.sub.C' is each independently selected from R.sub.C; R.sub.D' is each independently selected from R.sub.D; R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; X is ##STR00969## wherein X.sub.3 is N which is directly linked to -L.sub.3-D, and X is optionally substituted with one or more R.sub.A or R.sub.F; L.sub.1, L.sub.2, and L.sub.3 are bond; A is ##STR00970## and is optionally substituted with one or more R.sub.A; B is ##STR00971## and is optionally substituted with one or more R.sub.A; D is phenyl, and is substituted with J and optionally substituted with one or more R.sub.A; J is C.sub.3-C.sub.6carbocycle, 3- to 6-membered heterocycle, 6- to 12-membered bicycle, 10- to 15-membered tricycle, or 13- to 15-membered carbocycle or heterocycle, and J is optionally substituted with one or more R.sub.A; -T-R.sub.D' is each independently selected from --C(O)-L.sub.Y'-N(R.sub.B)C(O)--R.sub.D' or --C(O)-L.sub.Y'-N(R.sub.B)C(O)O--R.sub.D', wherein L.sub.Y' is each independently C.sub.1-C.sub.6alkylene and optionally substituted with one or more substituents selected from R.sub.L; R.sub.D is each independently selected at each occurrence from hydrogen or R.sub.A; R.sub.A is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -L.sub.S-R.sub.E, wherein two adjacent R.sub.A, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; R.sub.B is each independently selected at each occurrence from hydrogen; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.B is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.C is independently selected at each occurrence from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.C is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.E is independently selected at each occurrence from --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S'), --N(R.sub.S)C(O)R.sub.S', --N(R.sub.S)C(O)N(R.sub.S'R.sub.S''), --N(R.sub.S)SO.sub.2R.sub.S', --SO.sub.2N(R.sub.SR.sub.S'), --N(R.sub.S)SO.sub.2N(R.sub.S'R.sub.S''), --N(R.sub.S)S(O)N(R.sub.S'R.sub.S''), --OS(O)--R.sub.S, --OS(O).sub.2--R.sub.S, --S(O).sub.2OR.sub.S, --S(O)OR.sub.S, --OC(O)OR.sub.S, --N(R.sub.S)C(O)OR.sub.S', --OC(O)N(R.sub.SR.sub.S'), --N(R.sub.S)S(O)--R.sub.S', --S(O)N(R.sub.SR.sub.S'), --P(O)(OR.sub.S).sub.2, .dbd.C(R.sub.SR.sub.S'), or --C(O)N(R.sub.S)C(O)--R.sub.S'; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.12carbocycle, 3- to 12-membered heterocycle or 7- to 12-membered carbocycle or heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from (1) halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl, C.sub.2-C.sub.6haloalkynyl, --C(O)OR.sub.S, or --N(R.sub.SR.sub.S'), or (2) trimethylsilyl, --O--R.sub.S, --S--R.sub.S or --C(O)R.sub.S; R.sub.F is independently selected at each occurrence from C.sub.1-C.sub.10alkyl, C.sub.2-C.sub.10alkenyl or C.sub.2-C.sub.10alkynyl, each of which contains 0, 1, 2, 3, 4 or 5 heteroatoms selected from O, S or N and is optionally substituted with one or more R.sub.L; or --(R.sub.X--R.sub.Y).sub.Q--(R.sub.X--R.sub.Y'), wherein Q is 0, 1, 2, 3 or 4, and each R.sub.X is independently O, S or N(R.sub.B), wherein each R.sub.Y is independently C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene each of which is independently optionally substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano, and wherein each R.sub.Y' is independently C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl each of which is independently optionally substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; R.sub.L is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S') or --N(R.sub.S)C(O)R.sub.S'; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; wherein two adjacent R.sub.L, taken together with the atoms to which they are attached and any atoms between the atoms to which they are attached, can optionally form carbocycle or heterocycle; L.sub.S is each independently selected at each occurrence from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; and R.sub.S, R.sub.S' and R.sub.S'' are each independently selected at each occurrence from hydrogen; C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, --O--C.sub.1-C.sub.6alkyl, --O--C.sub.1-C.sub.6alkylene-O--C.sub.1-C.sub.6alkyl, or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.S, R.sub.S' or R.sub.S' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl.

3. The method of claim 2, wherein J is 3- to 6-membered heterocycle, and is optionally substituted with one or more R.sub.A.

4. The method of claim 2, wherein: X is optionally substituted with one or more R.sub.A; J is C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, and is optionally substituted with one or more R.sub.A; R.sub.L is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S') or --N(R.sub.S)C(O)R.sub.S'; or C.sub.3-C.sub.6carbocycle 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.A is independently selected at each occurrence from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; and R.sub.S, R.sub.S' and R.sub.S'' are each independently selected at each occurrence from hydrogen; C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.S, R.sub.S' or R.sub.S' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl.

5. The method of claim 4, wherein D is ##STR00972## and each R.sub.N is independently selected from R.sub.D.

6. The method of claim 5, wherein: R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form ##STR00973## which is optionally substituted with one or more R.sub.A; and R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form ##STR00974## which is optionally substituted with one or more R.sub.A.

7. The method of claim 6, wherein: R.sub.C' is hydrogen; and R.sub.D' is independently selected at each occurrence from C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl.

8. A method of treating HCV infection, comprising administering an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, and another anti-HCV agent, to an HCV patient in need thereof, ##STR00975## wherein: X is ##STR00976## wherein X.sub.3 is N which is directly linked to -L.sub.3-D, and X is optionally substituted with one or more R.sub.A; L.sub.1, L.sub.2 and L.sub.3 are bond; A is ##STR00977## and is optionally substituted with one or more R.sub.A; B is ##STR00978## and is optionally substituted with one or more R.sub.A; D is C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, and is optionally substituted with one or more R.sub.A; Y is -L.sub.S-C(R.sub.1R.sub.2)N(R.sub.S)--C(O)-L.sub.Y'-N(R.sub.B)C(O)O--R.su- b.D, -L.sub.S-C(R.sub.1R.sub.2)N(R.sub.S)--C(O)-L.sub.Y'-N(R.sub.B)C(O)--R- .sub.D; Z is -L.sub.S-C(R.sub.8R.sub.9)N(R.sub.12)--C(O)-L.sub.Y'-N(R.sub.B)C(O)O--R.s- ub.D or -L.sub.S-C(R.sub.8R.sub.9)N(R.sub.12)--C(O)-L.sub.Y'-N(R.sub.B)C(O- )--R.sub.D; L.sub.Y' is each independently C.sub.1-C.sub.6alkylene which is optionally substituted with one or more R.sub.L; R.sub.1 is R.sub.C; R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form a 5- to 6-membered heterocycle or 6- to 12-membered bicycle which is optionally substituted with one or more R.sub.A; R.sub.8 is R.sub.C; R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form a 5- to 6-membered heterocycle or 6- to 12-membered bicycle which is optionally substituted with one or more R.sub.A; R.sub.D is each independently selected at each occurrence from hydrogen or R.sub.A; R.sub.A is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -L.sub.S-R.sub.E; R.sub.B is independently selected at each occurrence from hydrogen; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.B is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.C is independently selected at each occurrence from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.C is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.E is independently selected at each occurrence from --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S'), --N(R.sub.S)C(O)R.sub.S', --N(R.sub.S)C(O)N(R.sub.S'R.sub.S''), --N(R.sub.S)SO.sub.2R.sub.S', --SO.sub.2N(R.sub.SR.sub.S'), --N(R.sub.S)SO.sub.2N(R.sub.S'R.sub.S''), --N(R.sub.S)S(O)N(R.sub.S'R.sub.S''), --OS(O)--R.sub.S, --OS(O).sub.2--R.sub.S, --S(O).sub.2OR.sub.S, --S(O)OR.sub.S, --OC(O)OR.sub.S, --N(R.sub.S)C(O)OR.sub.S', --OC(O)N(R.sub.SR.sub.S'), --N(R.sub.S)S(O)--R.sub.S', --S(O)N(R.sub.SR.sub.S') or --C(O)N(R.sub.S)C(O)--R.sub.S'; or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.6carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.L is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S') or --N(R.sub.S)C(O)R.sub.S'; or C.sub.3-C.sub.6carbocycle 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; L.sub.S is independently selected at each occurrence from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; and R.sub.S, R.sub.S' and R.sub.S'' are each independently selected at each occurrence from hydrogen; C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano or 3- to 6-membered carbocycle or heterocycle; or 3- to 6-membered carbocycle or heterocycle; wherein each 3- to 6-membered carbocycle or heterocycle in R.sub.S, R.sub.S' or R.sub.S' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl.

9. The method of claim 8, wherein: R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form ##STR00979## which is optionally substituted with one or more R.sub.A R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form ##STR00980## which is optionally substituted with one or more R.sub.A.

10. A method of treating HCV infection, comprising administering an effective amount of a compound of Formula I.sub.F or a pharmaceutically acceptable salt thereof, and another anti-HCV agent, to an HCV patient in need thereof, ##STR00981## wherein: X is ##STR00982## and is optionally substituted with one or more R.sub.A A is ##STR00983## and is optionally substituted with one or more R.sub.A; B is ##STR00984## and is optionally substituted with one or more R.sub.A; D is ##STR00985## wherein G.sub.3 is phenyl optionally substituted with one or two R.sub.G3; g is 0, 1, or 2; R.sub.M is each independently fluoro, chloro, methyl, methoxy, trifluoromethyl, or trifluoromethoxy; ##STR00986## is a monocyclic 4-8 membered nitrogen-containing heterocycle and is optionally substituted with one or more R.sub.G2; Y is -T'-C(R.sub.1R.sub.2)N(R.sub.5)-T-R.sub.D; Z is -T'-C(R.sub.8R.sub.9)N(R.sub.12)-T-R.sub.D; R.sub.1 is hydrogen, C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6haloalkyl, or 3- to 6-membered carbocycle or heterocycle, wherein each said 3- to 6-membered carbocycle or heterocycle in R.sub.1 is independently optionally substituted at each occurrence with one or more substituents selected from halogen, C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6haloalkyl, --O--C.sub.1-C.sub.6alkyl or --O--C.sub.1-C.sub.6haloalkyl; R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; R.sub.8 is hydrogen, C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6haloalkyl, or 3- to 6-membered carbocycle or heterocycle, wherein each said 3- to 6-membered carbocycle or heterocycle in R.sub.8 is independently optionally substituted at each occurrence with one or more substituents selected from halogen, C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6haloalkyl, --O--C.sub.1-C.sub.6alkyl or --O--C.sub.1-C.sub.6haloalkyl; R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle which is optionally substituted with one or more R.sub.A; T is independently selected at each occurrence --C(O)-L.sub.S'-; T' is bond; R.sub.D is each independently selected at each occurrence from hydrogen or R.sub.A; R.sub.A is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -L.sub.S-R.sub.E; R.sub.E is independently selected at each occurrence from --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S'), --N(R.sub.S)C(O)R.sub.S', --N(R.sub.S)C(O)N(R.sub.S'R.sub.S''), --N(R.sub.S)SO.sub.2R.sub.S', --SO.sub.2N(R.sub.SR.sub.S'), --N(R.sub.S)SO.sub.2N(R.sub.S'R.sub.S''), --N(R.sub.S)S(O)N(R.sub.S'R.sub.S''), --OS(O)--R.sub.S, --OS(O).sub.2--R.sub.S, --S(O).sub.2OR.sub.S, --S(O)OR.sub.S, --OC(O)OR.sub.S, --N(R.sub.S)C(O)OR.sub.S', --OC(O)N(R.sub.SR.sub.S'), --N(R.sub.S)S(O)--R.sub.S', --S(O)N(R.sub.SR.sub.S'), --C(O)N(R.sub.S)C(O)--R.sub.S', or .dbd.C(R.sub.SR.sub.S'); or C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.L is independently selected at each occurrence from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, --O--R.sub.S, --S--R.sub.S, --C(O)R.sub.S, --OC(O)R.sub.S, --C(O)OR.sub.S, --N(R.sub.SR.sub.S'), --S(O)R.sub.S, --SO.sub.2R.sub.S, --C(O)N(R.sub.SR.sub.S'), or --N(R.sub.S)C(O)R.sub.S'; or C.sub.3-C.sub.12carbocycle or 3- to 12-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; L.sub.S is independently selected at each occurrence from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each independently optionally substituted with halogen; L.sub.S' is independently selected at each occurrence from bond; or C.sub.1-C.sub.6alkylene, C.sub.2-C.sub.6alkenylene or C.sub.2-C.sub.6alkynylene, each of which is independently optionally substituted at each occurrence with one or more R.sub.L; R.sub.S, R.sub.S' and R.sub.S'' are each independently selected at each occurrence from hydrogen; C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl or C.sub.2-C.sub.6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, --O--C.sub.1-C.sub.6alkyl, --O--C.sub.1-C.sub.6haloalkyl, or 3- to 12-membered carbocycle or heterocycle; or 3- to 12-membered carbocycle or heterocycle; wherein each 3- to 12-membered carbocycle or heterocycle in R.sub.S, R.sub.S' or R.sub.S'' is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl or C.sub.2-C.sub.6haloalkynyl; R.sub.G2 is independently selected at each occurrence from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C.sub.1-C.sub.6alkyl, C.sub.2-C.sub.6alkenyl, C.sub.2-C.sub.6alkynyl, C.sub.1-C.sub.6haloalkyl, C.sub.2-C.sub.6haloalkenyl, C.sub.2-C.sub.6haloalkynyl, --O--R.sub.S, --C(O)OR.sub.S, --C(O)R.sub.S, or --N(R.sub.SR.sub.S'); and R.sub.G3 is independently selected at each occurrence from halogen, --C.sub.1-C.sub.6alkyl, --C(O)C.sub.1-C.sub.6alkyl, --C.sub.1-C.sub.6haloalkyl, --O--C.sub.1-C.sub.6alkyl, --O--C.sub.1-C.sub.6haloalkyl, C.sub.3-C.sub.6carbocycle, or 3- to 6-membered heterocycle.

11. The method of claim 10, wherein: R.sub.1 and R.sub.8 are hydrogen; R.sub.2 and R.sub.5, taken together with the atoms to which they are attached, form ##STR00987## and R.sub.9 and R.sub.12, taken together with the atoms to which they are attached, form ##STR00988##

12. The method of claim 11, wherein T-R.sub.D is independently selected at each occurrence from ##STR00989##

13. The method of claim 12, wherein D is ##STR00990## and R.sub.M1 is each independently hydrogen, fluoro, chloro, or methyl.

14. A method of treating HCV infection, comprising administering an effective amount of methyl {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piper- idin-1-yl]phenyl}-5-(6-fluoro-2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-th- reonyl]pyrrolidin-2-yl}-1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-- benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate or a pharmaceutically acceptable salt thereof, and another anti-HCV agent, to an HCV patient in need thereof.

15. The method of claim 14, wherein said another anti-HCV agent is an HCV polymerase inhibitor.

16. A method of treating HCV infection, comprising: making a pharmaceutical composition comprising methyl {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piper- idin-1-yl]phenyl}-5-(6-fluoro-2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-th- reonyl]pyrrolidin-2-yl}-1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-- benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate or a pharmaceutically acceptable salt thereof, and another anti-HCV agent; and administering said pharmaceutical composition to an HCV patient in need thereof.

17. The method of claim 16, wherein said another anti-HCV agent is an HCV polymerase inhibitor.

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