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Last Updated: March 29, 2024

Claims for Patent: 10,016,504


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Summary for Patent: 10,016,504
Title:Compositions
Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
Inventor(s): Clayton; Lucy (Uxbridge, GB), Cockett; Alasdair (Uxbridge, GB), Christodoulou; Mark (Uxbridge, GB), Davidson; Ian (Uxbridge, GB), Farrag; Lynn (Uxbridge, GB), Halphen; Marc (London, GB), Jones; Leighton (Uxbridge, GB), Petrossian; Vanik (Woburn, MA), Stein; Peter (Amsterdam Zuid-Oost, NL), Tisi; David (Woburn, MA), Ungar; Alex (Wigton, GB), Worthington; Jeffrey (Woburn, MA)
Assignee: NORGINE BV (Amsterdam Zuid-Oost, NL)
Application Number:15/454,132
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 10,016,504
Patent Claims: 1. A solution in water of: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid; and (ii) one or more salts of ascorbic acid; the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol.

2. A solution as claimed in claim 1 wherein the one or more salts of ascorbic acid are selected from sodium ascorbate, potassium ascorbate, magnesium ascorbate and calcium ascorbate, or a mixture thereof.

3. A solution as claimed in claim 1 wherein the molar ratio of the components (i) and (ii) is from 1:5.40 to 1:5.80.

4. A solution as claimed in claim 1 which comprises 60 to 140 g/liter of ascorbate component.

5. A solution as claimed in claim 4 which comprises 12 to 20 g/liter of ascorbic acid and 80 to 120 g/liter of sodium ascorbate.

6. A solution as claimed in claim 1 in which the polyethylene glycol has an average molecular weight of 2500 to 4500 Da.

7. A solution as claimed in claim 1 which comprises 60 to 100 g per liter of PEG.

8. A solution as claimed in claim 1 which comprises sodium chloride at a concentration of 4 to 7 g per liter.

9. A solution as claimed in claim 1 which comprises potassium chloride at a concentration of 1.5 to 3 g per liter.

10. A solution as claimed in claim 1 which comprises a flavouring agent and/or a sweetener.

11. A solution consisting essentially of: a) (i) 14 to 16 g per liter ascorbic acid; and (ii) 92 to 100 g per liter of sodium ascorbate; b) 75 to 85 g per liter PEG having an average molecular weight of 3000 to 4000 Da; c) 6.0 to 6.8 g per liter sodium chloride and 2.0 to 2.8 g per liter potassium chloride; d) one or more flavouring agents; and e) one or more sweeteners.

12. A solution as claimed in claim 11 consisting essentially of: a) (i) 15.08 g per liter ascorbic acid; and (ii) 96.22 g per liter sodium ascorbate; b) 80 g per liter PEG having an average molecular weight of 3000 to 4000 Da; c) 6.4 g per liter sodium chloride and 2.4 g per liter potassium chloride; d) orange flavouring, and e) 2.5 to 4.0 g per liter aspartame.

13. A solution as claimed in claim 1 which is a colon cleansing solution.

14. A method of preparing a solution as claimed in claim 1 comprising combining the components of the solution with water.

15. A method for preparing a solution wherein the method comprises combining a composition with water and admixing, wherein the composition is optionally presented in two or more parts and comprises: a) 150 to 400 mmol ascorbate anion provided by a mixture of: (i) ascorbic acid; and (ii) one or more salts of ascorbic acid; the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 5 to 100 g polyethylene glycol; and the volume of the solution is 300 ml to 1000 ml.

16. A method for preparing a solution as claimed in claim 15 wherein the volume of the solution is 450 ml to 550 ml.

17. A method as claimed in claim 15 wherein the composition comprises: a) (i) 6.0 to 10 g ascorbic acid; and (ii) 40 to 60 g sodium ascorbate; the components (i) and (ii) being present in a molar ratio of from 1:5063 to 1:7.875; and b) 30 to 50 g PEG having an average molecular weight of 3000 to 4000 Da; c) 1.5 to 4 g sodium chloride and 0.5 to 3.5 g potassium chloride; d) one or more flavouring agents; and e) one or more sweeteners; and the volume of the solution is 500 ml.

18. A method as claimed in claim 15 wherein the composition is optionally presented in two or more parts and comprises: a) (i) 7.0 to 8.0 g ascorbic acid; and (ii) 46 to 50 g sodium ascorbate; b) 37.5 to 42.5 g PEG having an average molecular weight of 3000 to 4000 Da; c) 2.0 to 3.2 g sodium chloride and 1.0 to 1.4 g potassium chloride; d) one or more flavouring agents; and e) one or more sweeteners; and the volume of the solution is 500 ml.

19. A method as claimed in claim 15 wherein the composition is optionally presented in two or more parts and comprises: a) (i) 7.54 g ascorbic acid; and (ii) 48.11 g sodium ascorbate; b) 40 g PEG having an average molecular weight of 3000 to 4000 Da; c) 3.20 g sodium chloride and 1.20 g potassium chloride; d) one or more flavouring agents; and e) one or more sweeteners; and the volume of the solution is 500 ml.

20. A solution prepared by the method as claimed in claim 15.

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