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Last Updated: March 28, 2024

Claims for Patent: 10,016,435


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Summary for Patent: 10,016,435
Title:Use of inhibitors of Bruton's tyrosine kinase (Btk)
Abstract: Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
Inventor(s): Buggy; Joseph J. (Mountain View, CA), Elias; Laurence (Berkeley, CA), Fyfe; Gwen (San Francisco, CA), Hedrick; Eric (Summit, NJ), Loury; David J. (Incline Village, NV), Mody; Tarak D. (Sunnyvale, CA)
Assignee: Pharmacyclics LLC (Sunnyvale, CA)
Application Number:15/715,995
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 10,016,435
Patent Claims: 1. A method for treating Waldenstrom's macroglobulinemia in an individual in need thereof, wherein the individual is treatment-nave for Waldenstrom's macroglobulinemia, comprising administering to the individual once per day about 420 mg of an oral dose of an inhibitor of Bruton's tyrosine kinase (Btk) having the structure: ##STR00044##

2. The method of claim 1, wherein the oral dose is a capsule.

3. The method of claim 1, wherein, following administration of the inhibitor, the individual achieves a stable disease, a partial response, or a complete response.

4. The method of claim 1, wherein, following administration of the inhibitor, the individual achieves a partial response or a complete response.

5. The method of claim 1, wherein, following administration of the inhibitor, the individual achieves a complete response.

6. The method of claim 1, wherein, following administration of the inhibitor, the individual does not experience a progressive disease.

7. The method of claim 1, wherein, following administration of the inhibitor, the individual achieves a stable disease.

8. The method of claim 1, wherein, following administration of the inhibitor, the individual achieves a partial response.

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