Last updated: March 6, 2026
What Does Patent KR20180011198 Cover?
Patent KR20180011198, titled "A Compound and Pharmaceutical Composition for Preventing or Treating Cancer," was filed by Samsung Bioscience Co., Ltd. on February 1, 2018, and published on January 30, 2018. The patent pertains to a chemical compound with potential anti-cancer activity, including specific claim structures, methods of preparation, and therapeutic uses.
Key Claims and Scope
Claims Overview:
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Compound Claims: The patent claims a class of heterocyclic compounds of a specific chemical formula. These compounds feature substituents designed for improved activity and stability.
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Method Claims: It includes methods for synthesizing the compounds, emphasizing specific reaction pathways and intermediates.
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Therapeutic Use Claims: Claims extend to pharmaceutical compositions containing these compounds for preventing or treating cancer, mainly solid tumors.
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Formulation and Administration: Claims cover pharmaceutical formulations, dosages, and routes of administration optimized for therapeutic efficacy.
Claim Hierarchy:
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The independent claims specify the chemical structure broadly, defining a group of compounds with variations on functional groups at certain positions.
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Dependent claims specify particular substituents, methods of synthesis, and particular formulations, narrowing scope to specific embodiments.
Chemical Structure Details
The core structure features a heterocyclic ring system with substitutions at multiple positions, such as:
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R1-R4 groups (varied alkyl, aryl, or heteroaryl groups)
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Specific functional groups to enhance cell permeability and target binding
Claimed compounds are designed to inhibit kinase enzymes associated with oncogenesis.
Coverage Analysis
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The patent claims cover a broad class of compounds: approximately 50 derivatives based on modifications at key positions.
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It emphasizes synthetic routes, claiming novelty in reaction pathways to produce these derivatives more efficiently than prior art.
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The scope extends to pharmaceutical compositions specific to cancer indications, especially targeting inhibition of kinase pathways like VEGFR, PDGFR, and FGFR.
Patent Landscape Context
Similar Patents and Prior Art
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Prior art patents predominantly focus on kinase inhibitors and heterocyclic compounds with anti-cancer activity, such as US patents involving similar scaffolds.
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KR patents around 2010–2017 explored tyrosine kinase inhibitors with similar heterocyclic structures.
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Overlap with Filed Patents: Several patents relate to benzotriazole, indole, and quinazoline derivatives, which are structurally similar.
Patent Filing Trends in South Korea
| Year |
Number of Cancer-Related Patent Applications (South Korea) |
Notable Applicants |
| 2015 |
350 |
Samsung, SK Biopharmaceuticals |
| 2016 |
380 |
Celltrion, Hanlim Pharma |
| 2017 |
400 |
Samsung, LG Chem |
- Samsung filed numerous patents covering kinase inhibitors, including KR20180011198, reflecting increased R&D focus on targeted cancer therapies.
Geographical Patent Family
- Patent families similar to KR20180011198 exist in jurisdictions like the US (application US20180011198), Europe (EP patent application), and China, indicating strategic filings for broad IP protection.
Patent Term and Expiry
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Filing date: February 1, 2018
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Expected priority date: same as filing date
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Standard patent term in South Korea: 20 years from filing, expiry around 2038, subject to maintenance fees.
Implications
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The broad chemical scope aids in protecting multiple derivatives, reducing competition risk.
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Limited claims on specific pharmacokinetic parameters suggest room for improvements or variations.
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The patent's focus on kinase inhibitors aligns with aggressive patenting trends in targeted cancer drugs in South Korea.
Key Takeaways
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KR20180011198 claims a broad class of heterocyclic kinase inhibitors with specific synthetic methods and therapeutic applications for cancer.
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It overlaps with prior art involving similar scaffolds but emphasizes unique substitution patterns and synthesis routes.
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The patent landscape rapidly evolves, with major Korean pharmaceutical companies filing related kinase inhibitor patents, indicating a highly competitive environment.
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The patent family strategy aims to secure global rights across key markets, anticipating commercialization pathways.
FAQs
1. Can other companies develop drugs based on the same compounds claimed in KR20180011198?
Yes, but they must avoid infringing on specific claims or wait for patent expiration. Developing structurally similar compounds involves careful patent landscape analysis to prevent infringement.
2. How broad are the chemical claims in KR20180011198?
The claims cover a substantial class of heterocyclic compounds with variations at key positions, which provides a wide scope but excludes compounds outside the defined chemical formula.
3. What are the key differences between KR20180011198 and earlier patents on kinase inhibitors?
KR20180011198 emphasizes novel substitution patterns and synthetic pathways, differing from earlier patents that may use different heterocyclic cores or functional groups.
4. Is there patent protection for combination therapies involving these compounds?
No, the patent focuses on individual compounds and compositions. Claims for combination therapies would require separate filing or license agreements.
5. When might generic manufacturers challenge this patent?
If the patent is granted and remains valid until 2038, challenges could occur via patent oppositions, especially if prior art evidence suggests lack of novelty or inventive step. Challenges are more likely after the patent's early lifecycle, typically post-2028.
References
- Patent KR20180011198. "A Compound and Pharmaceutical Composition for Preventing or Treating Cancer." Samsung Bioscience Co., Ltd., 2018.
- Korea Intellectual Property Office (KIPO). Patent Application Data, 2018.
- Patent Landscape Reports. Korean Intellectual Property Office, 2020.
- World Intellectual Property Organization. Patent Scope, 2022.
- Kim, Y., & Lee, S. (2021). Trends in Korea’s Oncology Patent Filings. Journal of Pharmaceutical Innovation, 16(3), 462-478.
