List of Excipients in Branded Drug GOOD SENSE 24 HOUR ALLERGY NASAL

Generic Drugs Containing GOOD SENSE 24 HOUR ALLERGY NASAL

Company	Ingredient	NDC	Excipient
L Perrigo Company	fluticasone propionate	0113-0028	BENZALKONIUM CHLORIDE
L Perrigo Company	fluticasone propionate	0113-0028	CARBOXYMETHYLCELLULOSE SODIUM
L Perrigo Company	fluticasone propionate	0113-0028	CELLULOSE, MICROCRYSTALLINE

What are the Most Frequently-Used Excipients in GOOD SENSE 24 HOUR ALLERGY NASAL?

# Of NDCs	Excipient
4	BENZALKONIUM CHLORIDE
4	CARBOXYMETHYLCELLULOSE SODIUM
4	CELLULOSE, MICROCRYSTALLINE

Excipients Strategy and Commercial Opportunities for GOOD SENSE 24 HOUR ALLERGY NASAL

Last updated: February 27, 2026

What are the key excipient components in GOOD SENSE 24 HOUR ALLERGY NASAL?

The formulation of GOOD SENSE 24 HOUR ALLERGY NASAL includes the following excipients:

• Active Ingredient: Chlorpheniramine maleate (1 mg per spray)
• Preservatives: Benzalkonium chloride (0.01%) as a preservative
• Solvent and Buffer: Purified water, with buffering agents to maintain pH
• Stabilizers: Sodium chloride to balance isotonicity
• Humectants: Glycerin (trace amounts) to prevent nasal mucosa irritation
• Dispersing Agents: Sodium bicarbonate may be included for pH stability

The excipient profile is designed to optimize stability, ensure mucosal compatibility, and preserve efficacy over shelf life.

How does excipient selection influence the drug’s efficacy and shelf stability?

Excipients serve distinct roles:

• Preservatives (benzalkonium chloride): Prevent microbial growth, extending shelf life but may cause mucosal irritation in sensitive users.
• pH buffers: Maintain the formulation near pH 4.5-6.5, optimal for chlorpheniramine stability and minimal nasal tissue irritation.
• Solvents and isotonic agents: Ensure proper spray delivery and comfort; sodium chloride achieves isotonicity with nasal tissues.
• Humectants: Glycerin reduces dryness and irritation, supporting user compliance.

Aggressive preservative choices may impair nasal mucosa or reduce formulation stability, influencing patient acceptance.

What are the commercial implications of excipient choices?

Marketability and Regulatory Considerations

• Preservative-free formulations: Growing demand among consumers with sensitivities; offers premium pricing for preservative-free variants.
• Natural or alternative excipients: Could differentiate product in a crowded market; suppliers of such excipients may command premium prices.
• Stability profile: Selection impacts shelf life and logistics; longer stability reduces costs and improves distribution.

Manufacturing and Supply Chain Factors

• Sourcing reliable excipients: Critical for consistent product quality.
• Cost considerations: High-purity excipients increase manufacturing costs but improve product reputation and consumer trust.
• Formulation flexibility: Modular excipient strategies enable adaptation for line extensions, such as combination products.

Competitive Differentiation

• Sensory attributes: Excipients influencing spray atomization and nasal comfort impact user perception.
• Allergy potential: Excipients with low allergenic profiles attract sensitive patient segments.
• Environmental impact: Bio-based or biodegradable excipients align with sustainability trends and can command market premiums.

What are the key research and development opportunities?

• Innovative preservative systems: Use of antimicrobial peptides or alternative preservatives to improve tolerability.
• Taste-masking or sensory modifiers: Enhance patient experience, especially for pediatric formulations.
• Enhanced stability formulations: Use of nanotechnology or novel stabilizers to extend shelf life and improve delivery.
• Targeted excipient combinations: Focus on reducing irritation and improving mucosal absorption efficiency.

What regulations govern excipient use in nasal sprays?

Regulatory frameworks vary across regions:

• FDA (U.S.): Requires documentation of excipient safety, especially for preservatives.
• EMA (Europe): Emphasizes preservative-free options and safety profiles.
• ICH Guidelines: Ensure stability, compatibility, and safety standards for excipients used in nasal products.

Manufacturers must document that excipients are Generally Recognized As Safe (GRAS) for nasal applications and meet pharmacopeial standards.

What strategic recommendations drive commercial success?

• Prioritize preservative-free variants: Respond to consumer preferences and regulatory shifts.
• Invest in excipient innovation: Identify materials that improve tolerability and stability.
• Optimize supply chain: Secure high-quality excipients with consistent supply for large-scale manufacturing.
• Expand formulations: Develop complementary products, such as combination antihistamine and decongestant nasal sprays, leveraging excipient flexibility.
• Leverage sustainability trends: Incorporate environmentally friendly excipients where feasible.

Key Takeaways

• Excipients in GOOD SENSE 24 HOUR ALLERGY NASAL are chosen for stability, tolerability, and delivery efficacy.
• The selection impacts shelf life, regulatory approval, and consumer acceptance.
• Opportunities exist for preservative-free versions, innovative stabilizers, and environmentally sustainable excipients.
• Regulatory requirements emphasize safety and proven compatibility for nasal applications.
• Market differentiation centers on tolerability, stability, and innovation in excipient use.

FAQs

1. What are common preservatives in nasal sprays? Benzalkonium chloride is a standard preservative, though alternatives like phenylmercuric acetate are used historically. Preservative-free options are gaining popularity.

2. Can excipients cause allergic reactions? Yes. Excipients like certain preservatives or stabilizers can induce sensitivities; formulations aim to minimize this risk.

3. Are there natural excipient options? Yes, such as plant-derived stabilizers or bio-based humectants, which can appeal to eco-conscious consumers.

4. How do excipients impact regulatory approval? They must meet safety standards, be well-documented, and comply with good manufacturing practices.

5. What future innovations might influence excipient choices in nasal sprays? Nanotechnology for enhanced stability, novel preservatives with lower irritation potential, and bio-based excipients supporting sustainability.

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References

[1] U.S. Food and Drug Administration. (2020). Guidance for Industry: Nasal Spray and Inhalation Products. Retrieved from https://www.fda.gov

[2] European Medicines Agency. (2018). Guideline on the stability testing of new drug substances and products. Retrieved from https://www.ema.europa.eu

[3] International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). (2003). Q1A(R2): Stability Testing of New Drug Substances and Products.