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Last Updated: October 18, 2019

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Drugs in Development Information for GBT440

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Development status for investigational drug GBT440: Sponsors, patents, clinical trial progress

GBT440 is an investigational drug.

There have been 14 clinical trials for GBT440. The most recent clinical trial was a Phase 2 trial, which was initiated on June 6th 2018.

The most common disease conditions in clinical trials are Anemia, Sickle Cell, Pulmonary Fibrosis, and Idiopathic Pulmonary Fibrosis. The leading clinical trial sponsors are Global Blood Therapeutics, National Heart, Lung, and Blood Institute (NHLBI), and Mayo Clinic.

There are ten US patents protecting this investigational drug and one hundred and seventy international patents.

Recent Clinical Trials for GBT440
TitleSponsorPhase
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)Phase 1
Study to Assess the Effect of Long-term Treatment With GBT440 in Participants Who Have Completed Treatment in Study GBT440-031Global Blood TherapeuticsPhase 3
Single-Dose PK and Safety Study of GBT440 in Subjects With Hepatic ImpairmentGlobal Blood TherapeuticsPhase 1

See all GBT440 clinical trials

Clinical Trial Summary for GBT440

Top disease conditions for GBT440
Top clinical trial sponsors for GBT440

See all GBT440 clinical trials

US Patents for GBT440

Drugname Patent Number Patent Title Patent Assignee Estimated Expiration
GBT440   Start Trial Methods of treatment Global Blood Therapeutics, Inc. (South San Francisco, CA)   Start Trial
GBT440   Start Trial Compounds and uses thereof for the modulation of hemoglobin Global Blood Therapeutics, Inc. (South San Francisco, CA)   Start Trial
GBT440   Start Trial Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation Global Blood Therapeutics, Inc. (South San Francisco, CA)   Start Trial
GBT440   Start Trial Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde Global Blood Therapeutics, Inc. (South San Francisco, CA)   Start Trial
GBT440   Start Trial Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde Global Blood Therapeutics, Inc. (South San Francisco, CA)   Start Trial
GBT440   Start Trial Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation Global Blood Therapeutics, Inc. (South San Francisco, CA) Cytokinetics, Inc. (South San Francisco, CA) The Regents of the University of California (Oakland, CA)   Start Trial
>Drugname >Patent Number >Patent Title >Patent Assignee >Estimated Expiration

International Patents for GBT440

Drugname Country Document Number Estimated Expiration Related US Patent
GBT440 Australia 2016243428 2035-03-30   Start Trial
GBT440 Brazil 112017020276 2035-03-30   Start Trial
GBT440 Canada 2980578 2035-03-30   Start Trial
GBT440 Chile 2017002435 2035-03-30   Start Trial
GBT440 China 107531671 2035-03-30   Start Trial
GBT440 Eurasian Patent Organization 201791998 2035-03-30   Start Trial
>Drugname >Country >Document Number >Estimated Expiration >Related US Patent

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