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Last Updated: May 10, 2024

CLINICAL TRIALS PROFILE FOR TIPIFARNIB

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Clinical Trials for Tipifarnib

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00003707 ↗	Combination Chemotherapy in Treating Patients With Advanced Cancer	Completed	National Cancer Institute (NCI)	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combining R115777 with gemcitabine in treating patients with advanced cancer.
NCT00003707 ↗	Combination Chemotherapy in Treating Patients With Advanced Cancer	Completed	The University of Texas Health Science Center at San Antonio	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combining R115777 with gemcitabine in treating patients with advanced cancer.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	National Cancer Institute (NCI)	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	University of Maryland Greenebaum Cancer Center	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	University of Maryland, Baltimore	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00005041 ↗	R115777 in Treating Patients With Relapsed Small Cell Lung Cancer	Completed	National Cancer Institute (NCI)	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of R115777 in treating patients who have relapsed small cell lung cancer.
NCT00005041 ↗	R115777 in Treating Patients With Relapsed Small Cell Lung Cancer	Completed	New York University School of Medicine	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of R115777 in treating patients who have relapsed small cell lung cancer.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Tipifarnib

Condition Name

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Condition Name for
Intervention	Trials
Untreated Adult Acute Myeloid Leukemia	8
Leukemia	8
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)	7
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities	7
[disabled in preview]	0
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Condition MeSH

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Condition MeSH for
Intervention	Trials
Leukemia	27
Leukemia, Myeloid	22
Leukemia, Myeloid, Acute	19
Leukemia, Myelomonocytic, Acute	13
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Clinical Trial Locations for Tipifarnib

Trials by Country

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Trials by Country for
Location	Trials
United States	356
Spain	15
United Kingdom	8
Canada	6
Germany	6
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Trials by US State

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Trials by US State for
Location	Trials
New York	22
Texas	22
California	22
Florida	18
Maryland	17
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Clinical Trial Progress for Tipifarnib

Clinical Trial Phase

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Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 3	3
Phase 2/Phase 3	1
Phase 2	46
[disabled in preview]	35
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Clinical Trial Status

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Clinical Trial Status for
Clinical Trial Phase	Trials
Completed	68
Recruiting	8
Terminated	5
[disabled in preview]	4
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Clinical Trial Sponsors for Tipifarnib

Sponsor Name

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Sponsor Name for
Sponsor	Trials
National Cancer Institute (NCI)	63
Kura Oncology, Inc.	8
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	7
[disabled in preview]	8
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Sponsor Type

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Sponsor Type for
Sponsor	Trials
NIH	65
Other	39
Industry	21
[disabled in preview]	0
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