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Last Updated: December 31, 2025

CLINICAL TRIALS PROFILE FOR SEMAXANIB

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Clinical Trials for Semaxanib

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00003720 ↗	SU5416 in Treating Patients With AIDS-Related Kaposi's Sarcoma	Completed	Pfizer	Phase 1	RATIONALE: SU5416 may stop the growth of Kaposi's sarcoma by stopping blood flow to the tumor. PURPOSE: Phase I trial to study the effectiveness of SU5416 in treating patients who have AIDS-related Kaposi's sarcoma.
NCT00004252 ↗	Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer	Completed	Pfizer	Phase 3	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. SU5416 may stop the growth of colorectal cancer by stopping blood flow to the tumor. It is not yet known whether chemotherapy is more effective with or without SU5416 in treating metastatic colorectal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of leucovorin and fluorouracil with or without SU5416 in treating patients who have metastatic colorectal cancer.
NCT00004868 ↗	SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy	Completed	National Cancer Institute (NCI)	Phase 1/Phase 2	RATIONALE: SU5416 may stop the growth of astrocytoma or glioma by stopping blood flow to the tumor. PURPOSE: Phase I/II trial to study the effectiveness of SU5416 in treating patients who have recurrent astrocytoma or mixed glioma that has not responded to previous radiation therapy.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Semaxanib

Condition Name

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Condition Name
Intervention	Trials
Sarcoma	5
Unspecified Adult Solid Tumor, Protocol Specific	4
Colorectal Cancer	3
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Condition MeSH

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Condition MeSH
Intervention	Trials
Sarcoma	5
Colorectal Neoplasms	3
Neoplasms	2
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Clinical Trial Locations for Semaxanib

Trials by Country

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Trials by Country
Location	Trials
United States	147
Canada	14
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Trials by US State

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Trials by US State
Location	Trials
California	11
Texas	9
Illinois	7
New York	7
Ohio	6
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Clinical Trial Progress for Semaxanib

Clinical Trial Phase

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Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	2
Phase 2	12
Phase 1/Phase 2	5
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Clinical Trial Status

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Clinical Trial Status
Clinical Trial Phase	Trials
Completed	21
Terminated	4
Unknown status	2
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Clinical Trial Sponsors for Semaxanib

Sponsor Name

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Sponsor Name
Sponsor	Trials
National Cancer Institute (NCI)	25
Case Comprehensive Cancer Center	3
Radiation Therapy Oncology Group	2
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Sponsor Type

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Sponsor Type
Sponsor	Trials
NIH	25
Other	18
Industry	2
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