CLINICAL TRIALS PROFILE FOR SAGE-718

Clinical Trials for SAGE-718

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT03770780 ↗	A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects	Completed	Sage Therapeutics	Phase 1	This study is a phase 1, double-blind, placebo-controlled crossover study of SAGE-718 using a ketamine challenge, to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic response using magnetic resonance imaging in healthy subjects
NCT03771586 ↗	A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects	Completed	Sage Therapeutics	Phase 1	This study is a phase 1, double-blind, placebo-controlled crossover study of single, oral dose of SAGE-718 using a ketamine challenge, to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects
NCT03787758 ↗	A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B	Completed	Sage Therapeutics	Phase 1	This study is a phase 1, double-blind, placebo-controlled, multiple ascending dose study to determine the safety, tolerability, and pharmacokinetics of SAGE-718 oral solution in healthy adults (Part A) with an open-label cohort of patients with Huntington's disease (Part B)
NCT03844906 ↗	A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects	Completed	Sage Therapeutics	Phase 1	This study is a Phase 1, randomized, double-blind, placebo-controlled study of multiple doses of SAGE-718 using ketamine challenge to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects.

Clinical Trial Conditions for SAGE-718

Condition Name

Condition Name for
Intervention	Trials
Cognitive Dysfunction	3
Healthy Volunteer	3
Huntington Disease	3
Mild Dementia	2

Condition MeSH

Condition MeSH for
Intervention	Trials
Cognitive Dysfunction	4
Huntington Disease	4
Alzheimer Disease	2
Parkinson Disease	2

Clinical Trial Locations for SAGE-718

Trials by Country

Trials by Country for
Location	Trials
United States	24

Trials by US State

Trials by US State for
Location	Trials
California	6
New Jersey	4
Nebraska	2
Maryland	2
Georgia	2

Clinical Trial Progress for SAGE-718

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	6
Phase 1	4

Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase	Trials
Not yet recruiting	5
Completed	5
Recruiting	1

Clinical Trial Sponsors for SAGE-718

Sponsor Name

Sponsor Name for
Sponsor	Trials
Sage Therapeutics	11

Sponsor Type

Sponsor Type for
Sponsor	Trials
Industry	11