A Multiple Dose Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04457845 in Healthy Volunteers
Completed
Pfizer
Phase 1
To determine if PF-04457845 at doses of 0.5mg, 1mg, 4mg, and 8 mg given once daily for 14
days will be safe and well tolerated in healthy volunteers. To determine the effect on food
on PF-04457845 pharmacokinetics and safety following administration of single doses of 4mg
and 8mg.
Evaluation Of The Relative Bioavailability Of PF-04457845 Tablet To Solution Formulation And Food Effect In Healthy Subjects
Completed
Pfizer
Phase 1
The purpose of this study is to estimate the bioavailability of PF-04457845 tablets relative
to solution and evaluate the effect of food (fasted vs. high fat meal) on the
pharmacokinetics of an oral tablet formulation of PF-04457845
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Completed
Pfizer
Phase 2
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain
and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme
in animals and healthy human volunteers. The purpose of this study is to evaluate whether
PF-04457845 can inactivate the FAAH enzyme in patients experiencing pain due to OA and
whether this results in these patients experiencing less pain.
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