A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
Active, not recruiting
Eli Lilly and Company
Phase 2
The main purpose of this study is to evaluate the efficacy and safety of ramucirumab or
merestinib or placebo plus cisplatin and gemcitabine in participants with advanced or
metastatic biliary tract cancer.
A Study in Advanced Cancers Using Ramucirumab (LY3009806) and Other Targeted Agents
Completed
Eli Lilly and Company
Phase 1
The main purpose of this study is to evaluate the safety of ramucirumab in combination with
other targeted agents in participants with advanced cancers.
A Study of Merestinib (LY2801653) in Healthy Participants
Completed
Eli Lilly and Company
Phase 1
The purpose of this study is to evaluate the effect of food on merestinib (standard meal and
high-fat meal) compared to the fasted state. The study will also measure how much of the
study drug gets into the blood stream and how long it takes the body to get rid of it. In
addition, the tolerability of the study drug will be evaluated. Information about any side
effects that may occur will also be collected. The study will last approximately 28 days.
Screening is required within 28 days prior to the start of the study.
A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors
Active, not recruiting
Eli Lilly and Company
Phase 1
The main purpose of this study is to evaluate the safety and tolerability of anti-programmed
cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced
refractory solid tumors.
Merestinib In Non-Small Cell Lung Cancer And Solid Tumors
Active, not recruiting
Eli Lilly and Company
Phase 2
This research study is examining merestinib (a targeted therapy) as a possible treatment for
non-small cell lung cancer (NSCLC) that was found to have a specific change in the MET gene
(a MET exon 14 mutation); or as a treatment for solid tumors that have an alteration in the
NTRK gene (an NTRK1, 2, or 3 rearrangement).
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