CLINICAL TRIALS PROFILE FOR MARIMASTAT
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Clinical Trials for Marimastat
Trial ID | Title | Status | Sponsor | Phase | Summary |
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NCT00002911 ↗ | Marimastat in Treating Patients With Stage III Non-small Cell Lung Cancer | Completed | ILEX Oncology Services, Incorporated | Phase 3 | RATIONALE: Marimastat may stop the growth of non-small cell lung cancer by stopping blood flow to the tumor. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of marimastat in treating patients who have residual stage III non-small cell lung cancer. |
NCT00003010 ↗ | Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy | Completed | National Cancer Institute (NCI) | Phase 3 | RATIONALE: Marimastat may stop the growth of breast cancer by stopping blood flow to the tumor. It is not known whether chemotherapy is more effective with or without marimastat for breast cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of marimastat with that of no further therapy in treating women who have metastatic breast cancer that is responding or stable after chemotherapy. |
NCT00003010 ↗ | Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy | Completed | North Central Cancer Treatment Group | Phase 3 | RATIONALE: Marimastat may stop the growth of breast cancer by stopping blood flow to the tumor. It is not known whether chemotherapy is more effective with or without marimastat for breast cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of marimastat with that of no further therapy in treating women who have metastatic breast cancer that is responding or stable after chemotherapy. |
NCT00003010 ↗ | Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy | Completed | Eastern Cooperative Oncology Group | Phase 3 | RATIONALE: Marimastat may stop the growth of breast cancer by stopping blood flow to the tumor. It is not known whether chemotherapy is more effective with or without marimastat for breast cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of marimastat with that of no further therapy in treating women who have metastatic breast cancer that is responding or stable after chemotherapy. |
NCT00003011 ↗ | Marimastat Following Chemotherapy in Treating Patients With Small Cell Lung Cancer | Completed | NCIC Clinical Trials Group | Phase 3 | RATIONALE: Marimastat may stop the growth of lung cancer by stopping blood flow to the tumor. It is not yet known if marimastat is an effective treatment for small cell lung cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of marimastat with a placebo following chemotherapy in treating patients who have small cell lung cancer. |
NCT00261391 ↗ | Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. | Completed | Boston Children's Hospital | Phase 1 | 3 patients were enrolled in each of 3 study cohorts. There three cohorts were given differing, incrementally larger doses of this phase I drug. The same safety measures are being obtained on all patients. Efficacy measures were individualized as enrolllees do not have the same underlying vascular anomaly. The study is structured to include a 24 month drug-phase and a 24 month follow-up phase. The study is now closed to enrollment. |
NCT00261391 ↗ | Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. | Completed | Boston Children’s Hospital | Phase 1 | 3 patients were enrolled in each of 3 study cohorts. There three cohorts were given differing, incrementally larger doses of this phase I drug. The same safety measures are being obtained on all patients. Efficacy measures were individualized as enrolllees do not have the same underlying vascular anomaly. The study is structured to include a 24 month drug-phase and a 24 month follow-up phase. The study is now closed to enrollment. |
>Trial ID | >Title | >Status | >Sponsor | >Phase | >Summary |
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