Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
Completed
Celerion
Phase 1
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of
rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of
child-bearing potential.
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
Completed
Madrigal Pharmaceuticals, Inc.
Phase 1
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of
rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of
child-bearing potential.
Drug Interaction Study of MGL-3196 With Atorvastatin
Completed
Celerion
Phase 1
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of
atorvastatin in healthy male subjects and female subjects not of child-bearing potential.
Drug Interaction Study of MGL-3196 With Atorvastatin
Completed
Madrigal Pharmaceuticals, Inc.
Phase 1
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of
atorvastatin in healthy male subjects and female subjects not of child-bearing potential.
Phase 2 Study of MGL-3196 in Patients With Non-Alcoholic Steatohepatitis (NASH)
Unknown status
Madrigal Pharmaceuticals, Inc.
Phase 2
The primary objective of this study is to determine the effect of once-daily oral MGL-3196 on
the percent change in hepatic fat fraction from baseline in patients with biopsy-proven
Non-alcoholic Steatohepatitis (NASH).
Study of MGL-3196 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)
Completed
Madrigal Pharmaceuticals, Inc.
Phase 2
The primary objective of this study is to determine the effect of once-daily oral MGL-3196 on
the percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in patients
with Heterozygous Familial Hypercholesterolemia (HeFH).
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