Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
Completed
Eastern Virginia Medical School
N/A
OBJECTIVES:
I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser
photodynamic therapy (PDT) in patients with corneal neovascularization.
II. Document the histopathologic mechanism of action in selected patients undergoing
penetrating keratoplasty following PDT therapy for corneal neovascularization.
III. Facilitate FDA product approval of DHP as a photosensitizing agent for laser treatment
in these patients.
IV. Explore the use of this photosensitizer for ocular and cutaneous basal cell and squamous
cell carcinoma.
Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
Completed
Medical College of Hampton Roads
N/A
OBJECTIVES:
I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser
photodynamic therapy (PDT) in patients with corneal neovascularization.
II. Document the histopathologic mechanism of action in selected patients undergoing
penetrating keratoplasty following PDT therapy for corneal neovascularization.
III. Facilitate FDA product approval of DHP as a photosensitizing agent for laser treatment
in these patients.
IV. Explore the use of this photosensitizer for ocular and cutaneous basal cell and squamous
cell carcinoma.
Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer
Completed
Roswell Park Cancer Institute
Phase 1
RATIONALE: Photodynamic therapy uses light and drugs that make cnacer cells more sensitive to
light to kill tumor cells. Brachytherapy uses radiation to damage tumor cells. Photodynamic
therapy combined with brachytherapy may kill more tumor cells.
PURPOSE: Phase I trial to study the effectiveness of photodynamic therapy plus brachytherapy
in treating patients with recurrent lung cancer that is blocking the lung passages.
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