Investigation Of The Effect Of Steady State Filibuvir On The Pharmacokinetics Of Oral Contraceptives (Levonorgestrel And Ethinyl Estradiol)
The purpose of this study is to estimate the effect of filibuvir on the pharmacokinetics of
ethinyloestradiol [EE] and levonorgestrel [LN], to assess the safety and tolerability of 600
mg BID of filibuvir in healthy women and to investigate the pharmacokinetics of 600 mg BID
of filibuvir in healthy women.
Filibuvir In Treatment Naive Hepatitis C Virus (HCV) Genotype 1 Subjects
The primary objective for this study is to determine if the addition of filibuvir to a
standard regimen of peginterferon/ribavirin (pegIFN/RBV) significantly increases the
proportion of subjects who achieve a sustained viral response (SVR) compared to
peginterferon/ribavirin (pegIFN/RBV) therapy alone.
Drug Interaction Study Of Filibuvir With Methadone Among Subjects On Chronic Methadone Maintenance
Filibuvir, a CYP3A4 inhibitor is being developed for the treatment of chronic Hepatitis C
infection. Given the likelihood of co administration of filibuvir and methadone, this study
will evaluate the effect of filibuvir on the pharmacokinetics of R/S Methadone.
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