CLINICAL TRIALS PROFILE FOR ELX-02

Clinical Trials for ELX-02

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02807961 ↗	Safety, Tolerability, Pharmacokinetics of ELX-02 in Healthy Adult Volunteers	Terminated	Cato Research	Phase 1	This is the first study in humans of ELX-02, an advanced synthetic aminoglycoside optimized as a translational read-through drug (TRID) for the treatment of genetic conditions caused by nonsense. mutations. This is a classical Phase 1a study designed as a randomized, double-blinded, placebo-controlled, single dose escalation to evaluate the safety, tolerability and pharmacokinetics of ELX-02 in healthy adult volunteers.
NCT02807961 ↗	Safety, Tolerability, Pharmacokinetics of ELX-02 in Healthy Adult Volunteers	Terminated	Eloxx Pharmaceuticals, Inc.	Phase 1	This is the first study in humans of ELX-02, an advanced synthetic aminoglycoside optimized as a translational read-through drug (TRID) for the treatment of genetic conditions caused by nonsense. mutations. This is a classical Phase 1a study designed as a randomized, double-blinded, placebo-controlled, single dose escalation to evaluate the safety, tolerability and pharmacokinetics of ELX-02 in healthy adult volunteers.
NCT03292302 ↗	Phase 1 Study of ELX-02 in Healthy Adults	Completed	SGS Life Sciences	Phase 1	Phase 1 Single Ascending Dose Study in Normal Healthy Volunteers
NCT03292302 ↗	Phase 1 Study of ELX-02 in Healthy Adults	Completed	SGS Life Sciences, a division of SGS Belgium NV	Phase 1	Phase 1 Single Ascending Dose Study in Normal Healthy Volunteers
NCT03292302 ↗	Phase 1 Study of ELX-02 in Healthy Adults	Completed	Eloxx Pharmaceuticals, Inc.	Phase 1	Phase 1 Single Ascending Dose Study in Normal Healthy Volunteers
NCT03309605 ↗	Phase 1 Study of ELX-02 in Healthy Adult Subjects	Completed	SGS Life Sciences	Phase 1	Phase 1 Multiple Ascending Dose Study in Normal Healthy Volunteers

Clinical Trial Conditions for ELX-02

Condition Name

Condition Name
Intervention	Trials
Genetic Disease	4
Nonsense Mutation	4
Cystic Fibrosis	2
Cystic Fibrosis With Meconium Ileus	1

Condition MeSH

Condition MeSH
Intervention	Trials
Genetic Diseases, Inborn	5
Fibrosis	2
Cystic Fibrosis	2
Meconium Ileus	1

Clinical Trial Locations for ELX-02

Trials by Country

Trials by Country
Location	Trials
United States	7
Australia	4
Germany	2
Belgium	2
United Kingdom	1

Trials by US State

Trials by US State
Location	Trials
Texas	1
Ohio	1
Massachusetts	1
Maryland	1
Colorado	1

Clinical Trial Progress for ELX-02

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	4
Phase 1	4

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	3
Recruiting	2
Terminated	2

Clinical Trial Sponsors for ELX-02

Sponsor Name

Sponsor Name
Sponsor	Trials
Eloxx Pharmaceuticals, Inc.	8
SGS Life Sciences	2
SGS Life Sciences, a division of SGS Belgium NV	2

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	9
Other	5