A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CC-99677 in Healthy Adult Subjects
Completed
Celgene
Phase 1
This is a phase 1, randomized, single-center, 3-part, FIH study to assess the safety,
tolerability, pharmacokinetics (PK, or how the drug behaves in the body), and
pharmacodynamics (PD, or what the drug does to the body) of single and multiple doses of
CC-99677 and to characterize the effect of food on the single-dose PK of CC-99677 in healthy
adult subjects.
A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677
Completed
Celgene
Phase 1
It is a phase 1, open-label, single-center, three-part study to assess the safety,
tolerability, and pharmacokinetics of multiple doses of CC-99677 administered alone or in
combination with either methotrexate and sulfasalazine; itraconazole, rifampin, midazolam, or
a cocktail of digoxin, metformin, and rosuvastatin in healthy subjects
A Study of CC-99677 in Participants With Active Ankylosing Spondylitis
Recruiting
Celgene
Phase 2
This study is designed to learn about response to CC-99677 treatment by measuring signs and
symptoms of Ankylosing Spondylitis (AS), objective measures of disease activity, quality of
life assessments, pharmacokinetics, safety, and tolerability over a 12-week double-blind
period.
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