Last Updated: June 23, 2026

CLINICAL TRIALS PROFILE FOR AMONAFIDE

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Clinical Trials for Amonafide

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00074100 ↗	Amonafide in Treating Women With Metastatic Breast Cancer That Has Progressed After Previous Chemotherapy	Completed	National Cancer Institute (NCI)	Phase 2	RATIONALE: Drugs used in chemotherapy, such as amonafide, work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of amonafide in treating women who have metastatic breast cancer that has progressed after previous chemotherapy.
NCT00074100 ↗	Amonafide in Treating Women With Metastatic Breast Cancer That Has Progressed After Previous Chemotherapy	Completed	Memorial Sloan Kettering Cancer Center	Phase 2	RATIONALE: Drugs used in chemotherapy, such as amonafide, work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of amonafide in treating women who have metastatic breast cancer that has progressed after previous chemotherapy.
NCT00087854 ↗	Study of Individualized Amonafide to Treat Prostate Cancer	Completed	Xanthus Pharmaceuticals, Inc.	Phase 1/Phase 2	The purpose of this study is to assess the safety and efficacy of Amonafide in men with androgen-independent prostate cancer, assigned to individualized doses of Amonafide based on acetylator phenotype information (doses adjusted on individual metabolism).
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Amonafide

Condition Name

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Condition Name
Intervention	Trials
Acute Myeloid Leukemia	2
Breast Cancer	1
Prostate Cancer	1
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Condition MeSH

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Condition MeSH
Intervention	Trials
Leukemia, Myeloid, Acute	3
Leukemia, Myeloid	3
Leukemia	3
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Clinical Trial Locations for Amonafide

Trials by Country

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Trials by Country
Location	Trials
United States	42
Australia	5
Canada	4
Russian Federation	2
Ukraine	2
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Trials by US State

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Trials by US State
Location	Trials
New York	4
California	3
Massachusetts	2
Illinois	2
Colorado	2
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Clinical Trial Progress for Amonafide

Clinical Trial Phase

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Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	3
Phase 1/Phase 2	1
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Clinical Trial Status

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Clinical Trial Status
Clinical Trial Phase	Trials
Completed	3
Unknown status	2
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Clinical Trial Sponsors for Amonafide

Sponsor Name

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Sponsor Name
Sponsor	Trials
Antisoma Research	2
Xanthus Pharmaceuticals, Inc.	2
National Cancer Institute (NCI)	1
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Sponsor Type

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Sponsor Type
Sponsor	Trials
Industry	4
Other	1
NIH	1
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