Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
Recruiting
Astex Pharmaceuticals
Phase 1/Phase 2
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660,
determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended
dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target
engagement data, in subjects with advanced solid tumors or lymphoma for whom standard
life-prolonging measures are not available.
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
Recruiting
Astex Pharmaceuticals, Inc.
Phase 1/Phase 2
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660,
determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended
dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target
engagement data, in subjects with advanced solid tumors or lymphoma for whom standard
life-prolonging measures are not available.
A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML)
Recruiting
Astex Pharmaceuticals, Inc.
Phase 1
To evaluate the safety, pharmacokinetics (PK), and efficacy of ASTX660 when given alone and
in combination with ASTX727 in participants with relapsed/refractory (R/R) acute myeloid
leukemia (AML). The duration of the study is expected to be approximately 30 months.
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