Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects
Completed
Actelion
Phase 1
The main objective of this study is to investigate whether repeated administration of a
cardiac medication (diltiazem) can affect the pharmacokinetics (i.e., amount and time of
presence in the blood) of ACT-541468
Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects
Completed
Idorsia Pharmaceuticals Ltd.
Phase 1
The main objective of this study is to investigate whether repeated administration of a
cardiac medication (diltiazem) can affect the pharmacokinetics (i.e., amount and time of
presence in the blood) of ACT-541468
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-541468 in Healthy Young Adults and Elderly Subjects
Completed
Actelion
Phase 1
The purpose of this study is to evaluate the tolerability, safety, pharmacokinetics (PK, or
amount of drug over time in the body) and pharmacodynamics (PD, or effects on the body) of
ACT-541468 following multiple ascending doses in healthy adults and following single
ascending doses in healthy elderly subjects when administered in the morning. The safety, PK
and PD of ACT-541468 will also be assessed after repeated evening administration of a
selected dose in both healthy adults and elderly.
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