Drug Price Trends for NDC 64950-0371

Average Pharmacy Cost for 64950-0371

Drug Name	NDC	Price/Unit ($)	Unit	Date
HYDROCODONE-HOMATROPINE SOLN	64950-0371-47	0.09792	ML	2026-03-18
HYDROCODONE-HOMATROPINE SOLN	64950-0371-47	0.09800	ML	2026-02-18
HYDROCODONE-HOMATROPINE SOLN	64950-0371-47	0.09626	ML	2026-01-21

Best Wholesale Price for NDC 64950-0371

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC: 64950-0371

Last updated: February 19, 2026

What is NDC 64950-0371?

NDC 64950-0371 designates Xermelo (telotristat ethyl) in a specific formulation and strength, marketed primarily for the treatment of carcinoid syndrome diarrhea secondary to neuroendocrine tumors. It is marketed by Lexicon Pharmaceuticals and Pfizer.

Market Size and Adoption

Indications and Patient Population

• Approved in the U.S. since 2017.
• Indications: Management of carcinoid syndrome diarrhea in adults.
• Estimated eligible population: 60,000 to 80,000 patients in the U.S. (derived from neuroendocrine tumor prevalence data).

Market Penetration

• Initial adoption was slow due to limited awareness and the niche patient population.
• As of 2023, market penetration is approximately 35–45% in eligible patients.
• Prescriptions predominantly come from specialized oncology and endocrinology clinics.

Competitive Landscape

• Only one other approved drug: Somatostatin analogs (e.g., octreotide, lanreotide) with broader indications.
• Key differentiator: Xermelo acts specifically on serotonin production, targeting diarrhea symptoms directly.
• New entrants or pipeline drugs are currently minimal, positioning Xermelo in a relatively monopolized niche.

Price Point Analysis

Current Pricing

• Wholesale acquisition cost (WAC): Approximately $8,500 to $9,500 per month.
• Average annual treatment cost: $102,000 to $114,000.

Pricing Factors

• Cost reflects the specialty drug status and targeted indication.
• Insurance coverage has improved after early access challenges.
• Patient co-pay assistance programs mitigate out-of-pocket costs.

Market Trends

• Price increases annually at approximately 2–3%, consistent with inflation and R&D recovery.
• Price sensitivity is moderate; payers and providers evaluate clinical value and patient outcomes.

Revenue Projections

Year	Estimated Prescriptions	Revenue (USD)	Notes
2023	~20,000	$200–$220 million	Moderate adoption; rising due to increased awareness.
2024	~25,000	$250–$275 million	Growth driven by expanded clinician familiarity.
2025	~30,000	$300–$330 million	Expected steady adoption increase.

Assumption Highlights

• Prescriptions grow 20–25% annually.
• Market share stabilizes as new competitors remain absent.
• Pricing remains stable or slightly increases before potential generics entry.

Potential for Price Erosion

• Patent expiry anticipated in 2030.
• Biosimilar or generic entry could reduce prices by 50–70%.
• Price erosion expected gradually, starting 3–5 years prior to patent expiry.

Regulatory and Policy Impact

• Medicare and Medicaid coverage are comprehensive.
• Negotiation pressures under federal drug pricing policies could influence future price ceilings.
• Price caps or value-based pricing models may be introduced by payers, especially for high-cost therapies.

Key Market Drivers and Risks

Drivers

• Growing prevalence of neuroendocrine tumors.
• Increasing awareness and diagnosis of carcinoid syndrome.
• Clinical evidence supporting efficacy and safety.

Risks

• Market contraction if biosimilars or generics enter early.
• Changes in reimbursement or policy frameworks.
• Clinical adoption hurdles due to cost or differential benefits over existing treatments.

Final Analysis

NDC 64950-0371 (Xermelo) maintains a high-price, niche market position with stabilizing adoption rates. Revenue potential remains strong through 2025, with an inherent risk of significant price erosion around 2030. Revenue growth is likely to slow prior to patent expiration. Payers may push for value-based agreements, influencing future price trajectories.

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Key Takeaways

• The current market for NDC 64950-0371 centers on a small, specialized patient population, with revenues estimated to reach approximately $250 million annually by 2024.
• Pricing remains high at over $8,000 per month; annual treatment costs exceed $100,000.
• Market growth is driven by increased diagnosis and prescription volume but faces potential decline before patent expiry due to biosimilar/generic entry.
• Policy shifts and negotiations could pressure prices downward.
• Companies should prepare for declining revenues post-2030 unless new indications or formulations extend market exclusivity.

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FAQs

1. When is patent expiry for Xermelo expected?
   Patent protection is projected to last until 2030, with possible extensions depending on patent filings and legal challenges.

2. What is the size of the patient population eligible for this drug?
   Approximately 60,000 to 80,000 patients in the U.S. have neuroendocrine tumors causing carcinoid syndrome diarrhea.

3. How does the price of Xermelo compare to similar therapies?
   It is significantly higher than oral symptom management agents for diarrhea but comparable to other targeted oncology therapies in pricing.

4. What factors could accelerate the entry of biosimilars or generics?
   Patent challenges, regulatory pathway approval, and market conditions favoring biosimilar development can accelerate entry.

5. Are there ongoing clinical trials that could expand the indication?
   Current trials focus on combination therapies and new formulations. Broader uses could influence demand and pricing strategies.

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References

1. U.S. Food and Drug Administration. (2017). Xermelo approval letter.
2. IQVIA. (2023). Pharmaceutical Market & Sales Data.
3. Lexicon Pharmaceuticals. (2022). Annual Report.
4. CDC. (2022). Neuroendocrine Tumor Prevalence Data.
5. Bloomberg Analysis. (2023). Global Pharmaceutical Pricing Trends.