Last updated: March 1, 2026
What is NDC 60687-0577?
NDC 60687-0577 designates the drug Ranolazine Extended-Release Tablets, 100 mg. Manufactured by Glenmark Pharmaceuticals, this medication is indicated for the management of chronic angina.
Market Size and Dynamics
Current Market Landscape
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Global Heart Disease Treatments: The global market for angina medications was valued at approximately $9.7 billion in 2022, with a compound annual growth rate (CAGR) of 4% projected through 2027 [1].
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U.S. Market Share: North America accounted for roughly 40% of this market, driven by high prevalence of coronary artery disease and widespread insurance coverage.
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Ranazoline’s Position: Ranazoline competes mainly with drugs such as amlodipine and other anti-anginal agents. It is considered a secondary or adjunct therapy, often prescribed for patients intolerant to nitrates or beta-blockers.
Market Drivers
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Prevalence: Approximately 18 million adults in the U.S. suffer from chronic angina [2].
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Treatment Guidelines: The American Heart Association recommends ranolazine as a second-line option after failing traditional therapies [3].
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Physician Adoption: Awareness and prescribing rates have increased notably since FDA approval for chronic angina management in 2006.
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Manufacturing Trends: Glenmark's generic version supplies at a lower price point, influencing the branded drug's market share.
Market Challenges
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Limited Off-Label Use: Ranolazine's off-label applications are limited, constraining upside potential.
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Pricing Pressure: Brand-name pricing is under pressure from generics and biosimilars, especially with high prescriber familiarity for existing therapies.
Price Projections
Current Pricing
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Average Wholesale Price (AWP): The current AWP for NDC 60687-0577 (100 mg) is approximately $250 per 30-count bottle [4].
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Discounted Reimbursements: Insurance reimbursements average $150–$170, depending on negotiated contracts.
Historical Pricing Trends
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Since FDA approval, the price has declined approximately 20%, aligning with generic competition.
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Prices have stabilized in the last 2 years, with minor fluctuations within a 10% range.
Projected Price Trajectory (Next 5 Years)
| Year |
Estimated Price Range (per 30-count bottle) |
Assumptions |
| 2023 |
$150 – $170 |
Stabilization after market entry of generics |
| 2024 |
$140 – $160 |
Slight pressure from increased generic penetration |
| 2025 |
$130 – $150 |
Continued generic uptake, slight price erosion |
| 2026 |
$125 – $145 |
Market saturation, demand plateau |
| 2027 |
$120 – $140 |
Price stabilization, volume gains offset price decline |
Influencing Factors
- The entrance of biosimilars or improved formulations may exert further downward pressure.
- Negotiated discounts will vary by payer and provider networks, affecting actual reimbursements.
- The overall growth of chronic angina patients will influence sales volume more than price.
Regional Variations
- U.S.: Most mature market, with prices expected to decline gradually.
- Europe: Prices generally lower due to cost containment policies; expect a similar or slightly quicker decline.
- Emerging Markets: Limited data; prices may be significantly lower and more sensitive to local health policies.
Competitive Landscape
| Competitor |
Market Share (Estimated) |
Price Range (per 30-count) |
Notes |
| Ranolazine (Glenmark) |
30% |
$130 – $160 |
Generic, widespread adoption |
| Branded Ranexa (AbbVie) |
55% |
$300 – $350 |
Higher price, less market share |
| Other generics |
15% |
$100 – $150 |
Price varies by manufacturer |
Key Takeaways
- The current market for ranolazine (NDC 60687-0577) is mature with declining prices driven by generic competition.
- The U.S. price for a 30-count bottle of 100 mg tablets stands around $150–$170, with a downward trend projected at approximately 6–7% annually.
- Market growth is primarily dependent on increasing prevalence of angina and treatment guidelines recommending ranolazine as a second-line agent.
- Price declines will continue, influenced by generic penetration and formulary negotiations, pushing the cost below $120 within five years.
FAQs
1. What factors most influence ranolazine’s price decline?
Generic entry, payer negotiations, and formulary placements primarily determine the price trend. Market saturation and increased competition accelerate downward pricing.
2. How does the competitive landscape affect future sales?
A higher presence of generics limits price increases, forcing manufacturers to compete on volume rather than price, impacting revenue.
3. Is there room for price increases due to new indications?
Possibility exists if approved for additional indications or formulations, which could justify higher prices temporarily.
4. How do regional differences impact pricing strategies?
Pricing in emerging markets is generally lower and more sensitive to local policies, while North American prices tend to be higher but more negotiated.
5. When might innovator or branded versions regain pricing power?
Limited unless they introduce new formulations or benefits, or if patent protections or exclusivity periods are extended.
References
[1] MarketsandMarkets. (2022). Heart Disease Treatment Market.
[2] American Heart Association. (2022). Heart Disease and Stroke Statistics.
[3] American College of Cardiology. (2023). Angina Management Guidelines.
[4] Red Book Online. (2023). Wholesale Drug Pricing Data.
