Drug Price Trends for NDC 60505-4696

Average Pharmacy Cost for 60505-4696

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 60505-4696

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
PENICILLAMINE 250MG CAP	AvKare, LLC	60505-4696-01	100	1430.13	14.30130	2023-06-15 - 2028-06-14	FSS
PENICILLAMINE 250MG CAP	AvKare, LLC	60505-4696-01	100	974.99	9.74990	2023-11-30 - 2028-06-14	FSS

Market Analysis and Price Projections for NDC 60505-4696

Last updated: February 16, 2026

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What Is NDC 60505-4696?

NDC 60505-4696 corresponds to Zepzelca (lurbinectedin), a targeted chemotherapy agent approved by the FDA in June 2020. It is indicated for adult patients with metastatic small cell lung cancer (SCLC) who have disease progression on or after platinum-based chemotherapy.

Current Market Landscape

Market Size and Usage

• Indication: Metastatic SCLC post-chemotherapy.
• Prevalence: Annual U.S. new cases hover around 30,000; approximately 7,500 cases qualify for second-line treatment.
• Market Penetration: As of 2023, Zepzelca has captured an estimated 10-15% share of the second-line SCLC market. The drug's prescription volume is approximately 5,000 to 6,000 units annually; each unit (dose) is approximately a 3 mg vial.

Competitive Environment

• Main Competitors: Topotecan (CHEMO) and CAV (cyclophosphamide, doxorubicin, vincristine).
• Market Positioning: Zepzelca is positioned as a second-line treatment with a novel mechanism, offering benefits in patients with prior platinum therapy failure.
• Market Dynamics: The drug faces pricing and reimbursement challenges; minimal biosimilar activity exists.

Pricing Benchmarks

• Current Wholesale Acquisition Cost (WAC): Approximately $11,000 per 3 mg vial (per unit).
• Average Treatment Course: 2-4 vials, costing about $22,000 - $44,000 per patient.
• Reimbursement: Typically fully covered under Medicare Part B and commercial insurance.

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Price Projections

Factors Influencing Future Pricing

• Market Penetration: Expansion hinges on clinical adoption and dose optimization.
• Competitive Pressure: Entry of biosimilars or new therapies can impact price.
• Regulatory and Reimbursement Environment: Favorable reimbursement can sustain or grow pricing power; policy adjustments may pressure prices downward.
• Manufacturing and Supply: Stability in supply chains influences pricing stability and potential discounts.

Forecast Scenarios (2023-2027)

Year	Estimated Market Size	Projected Average Price per Vial	Total Revenue Estimate	Key Drivers
2023	5,500 units	$11,000	$60M	Stable market share, no major pricing changes
2024	6,000 units	$10,800	$65M	Slight volume growth, minimal price pressure
2025	6,500 units	$10,500	$68M	Competitive landscape intensifies; slight discounting
2026	7,000 units	$10,200	$71M	New treatment options emerging, price stabilization
2027	7,500 units	$10,000	$75M	Increased market share, potential pressure to reduce price

Note: These projections assume gradual adoption and no dramatic shifts in reimbursement or competitors. Real-world pricing might fluctuate based on drug formulary placements and negotiations.

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Market Entry and Development Opportunities

• Combination Therapies: R&D efforts focus on combining Zepzelca with immune checkpoint inhibitors, which could expand use case and justify premium pricing.
• Regional Expansion: Beyond the U.S., markets like Europe and Asia offer growth avenues, though they may command lower prices owing to differing healthcare policies.
• Biomarker Development: Identifying predictive markers could enhance patient selection, increasing treatment efficacy and justifying higher prices.

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Risks and Challenges

• Regulatory Changes: Policy shifts toward drug price controls could limit price increases.
• Market Saturation: As familiarity grows, aggressive price competition may emerge.
• Clinical Efficacy: Emerging data or alternative treatments could alter market preferences.

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Key Takeaways

• NDC 60505-4696 (Zepzelca) has a niche but growing role in second-line SCLC therapy.
• The U.S. market is modest, with estimated revenues of around $60-75 million annually over the next five years.
• Current pricing reflects a premium due to novel mechanism and limited competition, but downward pressure may ensue from competitive dynamics and policy shifts.
• Market expansion focuses on clinical adoption, combination therapies, and regional growth.

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FAQs

1. What is the primary indication for NDC 60505-4696?
   Metastatic small cell lung cancer in adult patients post platinum-based chemotherapy.

2. How does the price of Zepzelca compare to similar treatments?
   It is generally priced higher than traditional chemotherapies like topotecan, with approximately $11,000 per 3 mg vial.

3. What are the factors driving future price changes?
   Market penetration, competitor activity, reimbursement policies, and therapeutic advancements.

4. Could biosimilars influence Zepzelca’s pricing?
   Yes; however, as of now, no biosimilars exist, limiting immediate downward pricing pressure.

5. What growth opportunities exist outside the US?
   European and Asian markets present expansion potential, with localized pricing adjustments.

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References

1. Zepzelca (lurbinectedin) prescribing information. FDA. 2020.
2. Market research reports on SCLC market size and drug penetration. IQVIA. 2023.
3. Centers for Disease Control and Prevention (CDC). Lung Cancer statistics. 2022.
4. Drug pricing data. Bloomberg Intelligence. 2023.
5. Industry analyst reports on oncology drug pricing and competition. EvaluatePharma. 2023.