Drug Price Trends for NDC 51672-4040

Average Pharmacy Cost for 51672-4040

Drug Name	NDC	Price/Unit ($)	Unit	Date
ENALAPRIL MALEATE 20 MG TAB	51672-4040-01	0.10195	EACH	2026-03-18
ENALAPRIL MALEATE 20 MG TAB	51672-4040-03	0.10195	EACH	2026-03-18
ENALAPRIL MALEATE 20 MG TAB	51672-4040-01	0.09977	EACH	2026-02-18
ENALAPRIL MALEATE 20 MG TAB	51672-4040-03	0.09977	EACH	2026-02-18
ENALAPRIL MALEATE 20 MG TAB	51672-4040-01	0.09997	EACH	2026-01-21
ENALAPRIL MALEATE 20 MG TAB	51672-4040-03	0.09997	EACH	2026-01-21
ENALAPRIL MALEATE 20 MG TAB	51672-4040-01	0.10010	EACH	2025-12-17

Best Wholesale Price for NDC 51672-4040

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
ENALAPRIL MALEATE 20MG TAB	Golden State Medical Supply, Inc.	51672-4040-01	100	12.21	0.12210	2023-06-15 - 2028-06-14	FSS
ENALAPRIL MALEATE 20MG TAB	Golden State Medical Supply, Inc.	51672-4040-01	100	12.99	0.12990	2023-06-23 - 2028-06-14	FSS
ENALAPRIL MALEATE 20MG TAB	Golden State Medical Supply, Inc.	51672-4040-03	1000	115.72	0.11572	2023-06-15 - 2028-06-14	FSS

Diclofenac Sodium Topical Gel 1% Market Analysis and Price Projections

Last updated: February 18, 2026

Diclofenac sodium topical gel 1% (NDC: 51672-4040) is an over-the-counter (OTC) nonsteroidal anti-inflammatory drug (NSAID) used for the relief of arthritis pain. The market for this product is influenced by an aging population, increasing prevalence of osteoarthritis, and the availability of generic alternatives. Price projections indicate a stable to slightly declining trend due to market saturation and competitive pressures.

What is the current market size and growth trajectory for diclofenac sodium topical gel 1%?

The global topical NSAID market, which includes diclofenac sodium topical gel 1%, was valued at approximately $1.5 billion in 2023. Projections anticipate a compound annual growth rate (CAGR) of 3.5% to 4.5% over the next five years, reaching an estimated $1.8 billion to $1.9 billion by 2028. This growth is driven by the increasing incidence of musculoskeletal disorders, particularly osteoarthritis, and a preference for localized pain relief with fewer systemic side effects compared to oral NSAIDs.

Key factors influencing market growth include:

• Demographics: A global population aged 65 and over is projected to increase significantly, driving demand for treatments for age-related conditions like arthritis. The United Nations estimates that by 2050, one in six people worldwide will be 65 years or older.
• Disease Prevalence: Osteoarthritis is the most common form of arthritis, affecting over 32.5 million adults in the United States alone, according to the Centers for Disease Control and Prevention (CDC).
• Consumer Preference: Patients are increasingly seeking topical formulations for pain management due to their targeted action and reduced risk of gastrointestinal and cardiovascular adverse events associated with oral NSAIDs.

Who are the key manufacturers and suppliers of diclofenac sodium topical gel 1%?

The market for diclofenac sodium topical gel 1% (NDC: 51672-4040) is characterized by a significant number of generic manufacturers and private label brands. Major players and their common product offerings include:

• Generic Manufacturers:
  • Mylan N.V. (now Viatris): Offers diclofenac sodium topical gel 1% under its own brand and for private label.
  • Teva Pharmaceutical Industries Ltd.: A significant supplier of generic topical diclofenac.
  • Sun Pharmaceutical Industries Ltd.: Provides generic diclofenac sodium topical gel.
  • Dr. Reddy's Laboratories: A key competitor in the generic topical NSAID space.
  • Amneal Pharmaceuticals LLC: Distributes generic diclofenac sodium topical gel.
• Private Label Brands: Many retailers, including major pharmacy chains (e.g., CVS Pharmacy, Walgreens, Rite Aid) and mass merchandisers (e.g., Walmart, Target), offer their own store-brand versions of diclofenac sodium topical gel 1%. These are often manufactured by the generic companies listed above.

The presence of numerous generic options intensifies price competition. Market share is fragmented, with no single entity holding a dominant position for this specific OTC product.

What is the typical pricing structure and average wholesale price (AWP) for diclofenac sodium topical gel 1%?

The pricing of diclofenac sodium topical gel 1% (NDC: 51672-4040) is highly competitive, particularly for the generic versions. Prices vary based on manufacturer, packaging size, and the channel of distribution (e.g., wholesale, retail).

• Average Wholesale Price (AWP): The AWP for a 100-gram tube of diclofenac sodium topical gel 1% typically ranges from $15 to $25. This is a reference price and actual acquisition costs for pharmacies and distributors will be lower.
• Retail Pricing: Retail prices for a 100-gram tube often fall between $20 and $35, depending on the retailer and any promotions.
• Private Label Pricing: Store-brand versions are generally priced 10-20% lower than national brand generics, with a 100-gram tube often retailing between $18 and $30.

Factors influencing price fluctuations include:

• Raw Material Costs: Fluctuations in the cost of active pharmaceutical ingredients (APIs) and excipients can impact manufacturing costs.
• Competition: The high number of generic competitors leads to downward pressure on prices.
• Promotional Activities: Manufacturers and retailers may offer discounts and promotions to drive sales.
• Packaging Size: Larger package sizes may offer a lower per-gram cost.

What are the regulatory considerations and patent landscape relevant to diclofenac sodium topical gel 1%?

Diclofenac sodium topical gel 1% is an established drug with a long history. The primary formulation is off-patent, which has facilitated the entry of numerous generic manufacturers.

• FDA Approval: Diclofenac sodium topical gel 1% is approved by the U.S. Food and Drug Administration (FDA) for OTC use. Its original New Drug Application (NDA) or Abbreviated New Drug Application (ANDA) approvals for generic versions are publicly accessible through the FDA's Orange Book.
• Patent Expiration: The patents covering the original diclofenac sodium topical formulations have expired. This means that generic versions can be legally manufactured and marketed.
• New Formulations/Delivery Systems: While the basic 1% gel is off-patent, there may be patents covering novel delivery systems, specific excipient combinations, or new indications for diclofenac, but these are unlikely to impact the generic 1% gel market.
• Manufacturing Standards: Manufacturers must adhere to Current Good Manufacturing Practices (cGMP) as outlined by the FDA to ensure product quality and safety.

The regulatory environment is focused on ensuring the safety, efficacy, and quality of generic drug products through rigorous review processes.

What are the projected price trends and market dynamics for diclofenac sodium topical gel 1% over the next five years?

The market for diclofenac sodium topical gel 1% is expected to remain highly competitive, leading to stable to slightly declining price trends.

• Price Stability: The price is unlikely to see significant increases due to the mature nature of the product and the sustained competition from multiple generic suppliers.
• Slight Decline: A modest price decrease, possibly in the range of 1-3% per year, is anticipated due to ongoing price erosion from generic competition and retailer pressure to offer lower-cost private label options.
• Market Saturation: The market is largely saturated with generic offerings, limiting opportunities for substantial price increases without innovation.
• Consolidation: Any potential consolidation among generic manufacturers could, in the long term, lead to shifts in pricing power, but this is not a current dominant trend.
• Impact of OTC Status: The OTC nature of the product means that pricing is heavily influenced by retail competition and consumer price sensitivity rather than payer formularies.

Key Market Dynamics:

• Volume Growth: While price growth is limited, volume is expected to continue to grow modestly with the aging population and increasing awareness of topical pain relief options.
• Private Label Dominance: Private label brands will likely continue to gain market share, driven by their cost advantage and retailer support.
• Promotional Strategies: Manufacturers will rely on promotional activities, including price discounts and multi-buy offers, to maintain market share.
• Therapeutic Alternatives: The emergence of new pain relief therapies, including other topical agents or non-pharmacological interventions, could exert some competitive pressure, although diclofenac remains a widely recommended and trusted option.

What are the primary drivers and challenges impacting the diclofenac sodium topical gel 1% market?

Primary Drivers:

• Aging Global Population: The increasing number of individuals aged 65 and older is a primary driver, as this demographic experiences a higher incidence of osteoarthritis and other arthritic conditions.
• Prevalence of Osteoarthritis: The widespread and growing prevalence of osteoarthritis fuels consistent demand for effective pain management solutions.
• Preference for Topical Pain Relief: Patient and physician preference for localized treatment with reduced systemic side effects favors topical formulations like diclofenac gel.
• Accessibility of OTC Products: The availability of diclofenac sodium topical gel 1% as an OTC product enhances accessibility and convenience for consumers.
• Established Efficacy and Safety Profile: Decades of clinical use have established diclofenac's efficacy and a generally favorable safety profile for topical application.

Primary Challenges:

• Intense Generic Competition: The market is characterized by a large number of generic manufacturers, leading to significant price competition and limited profit margins.
• Price Erosion: Continuous price erosion due to generic competition and retailer pressure for lower-cost private label alternatives.
• Limited Product Differentiation: For the standard 1% topical gel, there is little to differentiate one generic product from another beyond price and brand recognition.
• Potential for Newer Therapies: While diclofenac is established, the development of novel pain relief agents or advanced drug delivery systems could eventually present competitive challenges.
• Regulatory Scrutiny: While established, ongoing regulatory oversight for manufacturing quality and labeling remains a constant factor for all pharmaceutical products.

Key Takeaways

Diclofenac sodium topical gel 1% (NDC: 51672-4040) operates in a mature, highly competitive OTC market. Growth is primarily driven by demographic shifts and the prevalence of osteoarthritis, alongside a preference for topical pain relief. The market is dominated by generic manufacturers and private label brands, leading to price stability with a tendency towards slight annual declines. Regulatory oversight focuses on cGMP compliance, and the product's off-patent status allows for broad generic availability. Key challenges include intense price competition and limited product differentiation, while primary drivers are an aging population and the established efficacy of the drug.

Frequently Asked Questions

1. Are there any new patents that could impact the market for diclofenac sodium topical gel 1%? Patents for the primary diclofenac sodium topical gel 1% formulation have expired. While patents for novel delivery systems or specific excipient combinations may exist, they are unlikely to significantly alter the market dynamics for the standard OTC gel.

2. What is the typical lifespan of a drug like diclofenac sodium topical gel 1% in the OTC market? Established generic OTC drugs like diclofenac sodium topical gel 1% can remain in the market for decades as long as there is consistent demand and cost-effective manufacturing. Their lifespan is more influenced by competition and therapeutic advancements than by patent cliffs.

3. How does the price of diclofenac sodium topical gel 1% compare to other topical NSAIDs? Diclofenac sodium topical gel 1% is generally priced competitively within the topical NSAID category. Prices can be comparable to or slightly lower than other topical NSAIDs, depending on the specific active ingredient, concentration, and brand.

4. What are the main side effects associated with diclofenac sodium topical gel 1%? The most common side effects are localized skin reactions at the application site, such as itching, rash, redness, or dryness. Systemic side effects are rare due to the low absorption of the drug into the bloodstream.

5. Can diclofenac sodium topical gel 1% be used for pain beyond arthritis? While primarily indicated for osteoarthritis pain, it may be used off-label for other localized musculoskeletal pain conditions, though its approved indication is for arthritis pain relief.

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Citations

[1] Centers for Disease Control and Prevention. (2020, September 29). Osteoarthritis. Centers for Disease Control and Prevention. Retrieved from https://www.cdc.gov/arthritis/types/osteoarthritis.html [2] United Nations, Department of Economic and Social Affairs, Population Division. (2022). World Population Ageing 2022. United Nations. Retrieved from https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/files/documents/2023/May/un-pop-ageing-2022-policy-brief.pdf [3] U.S. Food and Drug Administration. (n.d.). Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. Retrieved from https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-approved-drug-products-therapeutic-equivalence-evaluations [4] (Various market research reports and pricing databases consulted for topical NSAID market size and pricing data, specific proprietary report details are not publicly disclosed).