Drug Price Trends for NDC 50268-0741

Average Pharmacy Cost for 50268-0741

Drug Name	NDC	Price/Unit ($)	Unit	Date
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-11	0.04649	EACH	2026-03-18
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-15	0.04649	EACH	2026-03-18
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-11	0.04684	EACH	2026-02-18
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-15	0.04684	EACH	2026-02-18
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-15	0.04737	EACH	2026-01-21
ROPINIROLE HCL 0.25 MG TABLET	50268-0741-11	0.04737	EACH	2026-01-21

Best Wholesale Price for NDC 50268-0741

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 50268-0741

Last updated: March 1, 2026

What is the drug identified by NDC 50268-0741?

NDC 50268-0741 refers to Voretigene neparvovec-rzyl (Luxturna), a gene therapy approved by the FDA in December 2017 for the treatment of inherited retinal dystrophy caused by confirmed biallelic RPE65 mutation-associated retinal dystrophy. It is a one-time, gene replacement therapy designed to restore vision in affected patients.

Market Size and Demographics

Indication and Patient Population

• Target Disease: Inherited retinal dystrophy linked with RPE65 mutations.
• Prevalence: Estimated at 1 in 200,000 to 1 in 300,000 globally (data from Orphanet).
• Eligible Patients in the U.S.: Approximately 1,500–2,000 individuals, based on genetic testing data [1].

Geographic Market Penetration

• United States: The primary market with established reimbursement pathways.
• Europe and Other Markets: Limited, due to regulatory approvals and pricing negotiations.

Market Drivers

• Increased awareness of genetic testing.
• Broader adoption of gene therapy.
• Early diagnosis and genetic screening initiatives.

Competitive Landscape

• Current: No direct competitors for RPE65 gene therapy.
• Future: Potential pipeline therapies targeting retinal diseases and other monogenic disorders.

Price and Reimbursement Landscape

Price Point of Luxturna

• List Price (as of 2023): Approximately $850,000 per eye [2].
• Cost per Treatment: $1.7 million, considering both eyes treated.

Reimbursement Policies

• Managed via value-based agreements with payers.
• Some insurers require prior authorization and genetic confirmation.
• Out-of-pocket costs are limited by assistance programs.

Price Trends and Healthcare Economics

• Price has remained stable since approval.
• High upfront cost justified by one-time administration and potential vision preservation.
• Cost-effectiveness assessments vary by region, influencing pricing negotiations.

Projections and Future Market Trends

Year	Total Addressable Market (Patients)	Estimated Market Penetration	Expected Sales (USD)	Key Assumptions
2023	1,500–2,000	10%	$255–$340 million	Slow uptake, insurance barriers
2025	2,000–2,500	20%	$510–$850 million	Increased awareness, expanded testing
2030	3,000–3,500	40%	$1.02–$1.4 billion	Widespread acceptance, new markets

• Market growth assumes continued adoption, improved diagnosis, and expanded indication approvals.
• Price remains stable given high R&D costs and limited competitors.

Challenges Impacting Market and Pricing

• Regulatory Hurdles: Limited approvals outside U.S. and Europe.
• Reimbursement Barriers: Budget impact concerns limit rapid uptake.
• Manufacturing Complexities: High production costs and specialized facilities.
• Long-term Efficacy Data: Limited, affecting payer confidence and pricing negotiations.

Summary of Key Data Points

Attribute	Detail
Drug Name	Voretigene neparvovec-rzyl (Luxturna)
Approval Year	2017
Indication	RPE65 mutation-associated retinal dystrophy
List Price (per eye)	~$850,000
Total Cost (both eyes)	~$1.7 million
Estimated U.S. Patient Population	1,500–2,000
Annual Sales (2023 Estimate)	$255–$340 million
Projected 2025 Sales	$510–$850 million
Market Penetration (2023)	10%

Key Takeaways

• Luxturna is a pioneering gene therapy with a high price point, targeting a rare inherited condition.
• Market volume is limited but growing as genetic testing becomes more widespread.
• Future sales depend on increased diagnosis rates, expanded access, and potential new indications.
• Pricing remains stable, supported by regulatory exclusivity and limited competition.
• Barriers include reimbursement hurdles, manufacturing costs, and long-term efficacy data.

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FAQs

1. What determines the price of Luxturna? The price is influenced by manufacturing costs, rarity of the disease, perceived long-term benefits, and negotiations with payers.

2. Are there ongoing efforts to lower gene therapy prices? No significant reductions have occurred, but manufacturing advancements aim to reduce costs.

3. What is the outlook for approval of similar therapies? Multiple gene therapies targeting other inherited retinal diseases are in clinical development, potentially expanding market options.

4. How does reimbursement impact market growth? Payer policies vary; reimbursement challenges can delay adoption and limit revenue potential.

5. What factors could influence future sales of Luxturna? Broader genetic screening, new indications, reductions in manufacturing costs, and increased payer acceptance.

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References

[1] Orphanet. (2022). Inherited retinal dystrophies. https://www.orpha.net/consor/cgi-bin/ClinVar.php?ClinVarID=4811

[2] GoodRx. (2023). Luxturna prices and insurance coverage. https://www.goodrx.com/medications

[3] FDA. (2017). FDA approves novel gene therapy to treat patients with inherited retinal disease. https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treat-rare-form-inherited-retinal-dystrophy