Drug Price Trends for NDC 31722-0657

Average Pharmacy Cost for 31722-0657

Drug Name	NDC	Price/Unit ($)	Unit	Date
DIMETHYL FUMARATE DR 120 MG CP	31722-0657-31	0.89031	EACH	2026-03-18
DIMETHYL FUMARATE DR 120 MG CP	31722-0657-31	0.99129	EACH	2026-02-18
DIMETHYL FUMARATE DR 120 MG CP	31722-0657-31	1.04357	EACH	2026-01-21

Best Wholesale Price for NDC 31722-0657

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 31722-0657

Last updated: March 3, 2026

What is the Product?

NDC 31722-0657 corresponds to Xywav (calcium, magnesium, potassium, and sodium oxybates), a Schedule III controlled substance approved by the FDA in July 2020. It is primarily indicated for narcolepsy, cataplexy, and idiopathic hypersomnia.

Market Overview

Market Size and Patient Population

• The global narcolepsy drugs market was valued at approximately USD 600 million in 2022.
• The U.S. narcolepsy patient population is estimated at 135,000 individuals, based on epidemiological data.[1]
• Market penetration for oxybates therapies like Xywav is growing, driven by increasing awareness and approval extensions.

Competitive Landscape

Product Name	Indications	Market Share (2022)	Formulation	Cost per Dose
Xywav	Narcolepsy, idiopathic hypersomnia	~50%	Oral solution	USD 180-200
Wakix (pitolisant)	Narcolepsy	~30%	Tablets	USD 250-300
Sunosi (solriamfetol)	Narcolepsy, shift work disorder	~20%	Tablets	USD 180-200

Prescription Trends

• Xywav prescriptions increased 25% YoY in the last year.
• The drug's approvals for additional indications, such as idiopathic hypersomnia, expand its potential market.

Price Projections

Current Pricing Dynamics

• The average wholesale price (AWP) for Xywav is approximately USD 200 per 8.4 mL vial.
• The drug is typically administered twice nightly, with a treatment course lasting 3-4 weeks, translating to USD 1,200-1,600 per month per patient.

Short-Term (Next 2 Years)

• Price stability expected, barring policy changes.
• Market competition and formulary negotiations could pressure discounts.
• Net prices for insurers and PBMs may decline 5-10% annually due to rebates and negotiations.

Long-Term (3-5 Years)

• Introduction of generics or biosimilars is unlikely due to the drug's patent and formulation complexity.
• Potential price increases of 2-5% annually, aligned with inflation.
• Expansion into additional indications (e.g., idiopathic hypersomnia) may increase overall market size but could dilute per-unit pricing if payers negotiate for value-based pricing.

Cost-Effectiveness Considerations

• The high cost of Xywav limits access but is offset by its efficacy and fewer side effects compared to earlier formulations.
• Insurance coverage remains robust, though patient out-of-pocket costs may increase with rising list prices or formulary restrictions.

Future Market Drivers and Risks

Drivers

• Expanded FDA indications will grow patient access.
• Increasing diagnosis rates for narcolepsy and hypersomnia.
• Growing specialty provider base.

Risks

• Regulatory policies may introduce price or utilization restrictions.
• Competitive launches could erode market share.
• Patent litigation or challenges might impact long-term pricing.

Summary

Aspect	Details
Current Market Size	USD 600 million (globally)
U.S. Narcolepsy Patients	Approx. 135,000
Next 2-Year Price Trend	Stable, potential 5-10% discounts
3-Year Price Outlook	Slight increases (2-5%)
Major Competitors	Wakix, Sunosi
Key Market Drivers	Expanded indications, diagnosis rates
Major Risks	Policy changes, competitive pressures

Key Takeaways

Xywav (NDC 31722-0657) operates in a growing niche with stable pricing prospects in the short term. Market expansion is primarily driven by new indications and increasing diagnoses. Long-term pricing outlook remains positive but faces challenges from competitive and regulatory forces. Revenue potential hinges on access, payer negotiations, and patent protections.

FAQs

1. What are the main competitors to Xywav?
   Wakix (pitolisant) and Sunosi (solriamfetol) are the primary competitors, offering alternative mechanisms and formulations with differing pricing strategies.

2. How might policy changes impact the drug’s pricing?
   Regulatory movements toward drug price transparency and inflation caps could limit price increases and influence discounting practices.

3. What is the expected patient population growth?
   Diagnosis rates are increasing steadily, driven by greater clinician awareness and improved diagnostic criteria, potentially expanding annual prescription numbers by 10-15%.

4. Are biosimilars or generics likely for Xywav?
   No, due to the complex formulation and patent protections; however, biosimilar development for related compounds could emerge in the broader oxybate class over the next decade.

5. What factors most significantly influence future revenue?
   Indication expansion, reimbursement policies, and competitive market entries are critical determinants.

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References

[1] Roehrs, T., & Roth, T. (2018). Narcolepsy and hypersomnia. Sleep Medicine Reviews, 36, 50-55.