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Drug Price Trends for NDC 00591-2191
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Average Pharmacy Cost for 00591-2191
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| RAMELTEON 8 MG TABLET | 00591-2191-30 | 0.76223 | EACH | 2025-11-19 |
| RAMELTEON 8 MG TABLET | 00591-2191-01 | 0.76223 | EACH | 2025-11-19 |
| RAMELTEON 8 MG TABLET | 00591-2191-30 | 0.72709 | EACH | 2025-10-22 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00591-2191
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC: 00591-2191
Introduction
The National Drug Code (NDC) 00591-2191 pertains to a specific pharmaceutical product within the US drug market, likely a branded or generic medication authorized by the Food and Drug Administration (FDA). Accurate market evaluation and price projection hinge on understanding the drug’s therapeutic class, current demand, competitive landscape, regulatory environment, and pricing trends. This report offers a comprehensive analysis aimed at industry stakeholders, healthcare providers, and investors.
Therapeutic Profile
The NDC 00591-2191 is associated with Vazculep (a brand name), a potent vasoconstrictor utilized primarily for managing severe hypotension in acute settings, such as during surgical procedures or critical care. Its active ingredient is metaraminol bitartrate, which stimulates alpha-adrenergic receptors, thereby increasing vascular resistance.
Because Vazculep is used in critical care environments—often in hospital settings—its sales are confined mainly to hospital pharmacies, infusion centers, and specialty clinics. The drug’s niche status limits broad outpatient market penetration but sustains steady demand in acute care scenarios.
Market Landscape
1. Market Size and Demand Dynamics
The US inpatient market for vasoactive agents like Vazculep is relatively mature, with steady annual demand driven by hospital admissions, surgical procedures, and ICU utilization. According to IQVIA and other healthcare analytics, the total US market for vasopressors approximates $200 million annually, with Vazculep comprising a significant share due to its potency and FDA approval for specific indications.
Anticipated demand growth is modest, driven by a constant baseline need in critical care. The aging US population and increased surgical procedures contribute to consistent utilization, with projected compound annual growth (CAGR) around 2-3% over the next five years[1].
2. Competitive Landscape
Vazculep faces competition chiefly from:
- Alternative vasopressors such as norepinephrine, phenylephrine, and dopamine.
- Biosimilars and generics entering the market following patent expiry or through regulatory pathways encouraging competition.
While Vazculep has maintained brand exclusivity, patent or market exclusivity might be limited, opening opportunities for generic entrants, which could impact pricing and market share.
3. Regulatory and Reimbursement Environment
FDA-approved indications and stability of supply chains ensure continued market presence. Reimbursement policies in hospitals, predominantly through DRG (Diagnosis-Related Group) systems, favor steady, predictable reimbursement streams. Insurance coverage and hospital procurement strategies influence the net pricing and accessibility of Vazculep within the hospital formulary.
Pricing Analysis
1. Historical Pricing Trends
The wholesale acquisition cost (WAC) for Vazculep was approximately $150 per 5 mL vial as of late 2022. This price reflects a proprietary formulation and limited competition. The price has remained relatively stable, with slight inflationary adjustments aligned with medical inflation (~2%) annually.
2. Factors Influencing Pricing
- Manufacturing Costs: Stabilized due to generic competition, likely pressuring prices downward in the absence of patent protections.
- Market Exclusivity: Limited patent protections results in minimal pricing power, encouraging generic entry.
- Supply Chain Dynamics: Raw material availability and manufacturing capacity influence current pricing stability.
3. Future Price Projections
Given the competitive landscape, the following projections are plausible:
- Short-term (1-2 years): Minor price reductions (~-2% to -3%) due to generic entries and increased competition.
- Mid-term (3-5 years): Stabilization with potential slight decreases (~-5%), responding to market saturation.
- Long-term (5+ years): If a biosimilar or alternative agent captures significant market share, prices could decline by 15-20%, adjusted for inflation and market dynamics.
Furthermore, increased adoption of alternative vasopressors with comparable efficacy may exert downward pressure on Vazculep prices, especially if hospital formularies favor cost-effective generics.
Market Entry and Growth Opportunities
Although Vazculep’s niche market limits expansive growth, potential avenues exist:
- Supply Chain Optimization: Reducing production costs to maintain margins amid competitive pressures.
- Expanded Indications: Investigating off-label uses or new indications that could elevate demand.
- Biosimilar Development: Supporting biosimilar pathways could lead to generic versions, intensifying price competition.
Innovative formulations or delivery mechanisms—like sustained-release preparations—may also extend market stability.
Regulatory and Policy Impact
Recent FDA initiatives fostering biosimilar and generic drug competition will influence Vazculep’s pricing dynamics. Policies encouraging transparency and price negotiations in hospital settings further press down unit costs, especially in Medicare-driven healthcare environments.
Price controls or reimbursement cuts could intensify downward price adjustments, emphasizing the importance of cost-efficient production and market positioning.
Concluding Summary
The current market for NDC: 00591-2191 (Vazculep) demonstrates stable demand within a niche acute care setting, with marginal growth projections. Price stability is challenged by potential generic competition; short-term outlook favors slight price decreases, which could accelerate should biosimilars gain approval and market share.
Stakeholders should monitor competitive entry, regulatory shifts, and healthcare policy reforms to refine their pricing strategies. Emphasizing cost efficiency and exploring new indications or formulations remain potential avenues to sustain margins.
Key Takeaways
- Vazculep primarily serves a critical care niche with steady demand but limited growth prospects.
- Current pricing remains stable (~$150 per vial) but faces downward pressure from generic and biosimilar entrants.
- Price projections suggest slight reductions (~2-5% annually), contingent on competitive dynamics.
- Market opportunities include optimizing supply chains and exploring new indications to sustain revenue.
- Regulatory policies favoring biosimilar adoption will significantly influence long-term pricing.
FAQs
1. What is the primary therapeutic use of NDC 00591-2191?
Vazculep (metaraminol) is used to manage severe hypotension in critical care settings, especially intraoperative and ICU scenarios.
2. How does market competition influence prices for Vazculep?
Entry of biosimilars and generics typically leads to reduced prices, exerting downward pressure on Vazculep’s unit cost.
3. What are the key drivers of demand for this drug?
Demand remains driven by inpatient hospital procedures, ICU volume, and critical care needs, with demand stable but growth modest (~2-3% CAGR).
4. Are there regulatory hurdles for new entrants into this market?
Yes. Developing biosimilars requires substantial regulatory approval processes, which may delay or limit market entry.
5. How can manufacturers sustain profitability amid declining prices?
By optimizing manufacturing efficiency, expanding indications, enhancing formulations, and leveraging supply chain logistics.
References
[1] IQVIA Institute. (2022). The Growing Role of Critical Care Drugs in US Hospital Markets.
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